A structure parameter for porous pharmaceutical tablets obtained with the aid of Wiener bounds for effective permittivity and terahertz time-delay measurement
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2016
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Degree programme
Language
en
Pages
6
87-92
87-92
Series
International Journal of Pharmaceutics, Volume 506, issue 1-2
Abstract
A structure parameter that can be used to predict the pattern of arrangement of porous inclusions in pharmaceutical tablets is introduced. By utilizing the effective refractive index of a pharmaceutical tablet obtained from terahertz time-domain measurements, we have shown that there exists a promising correlation between the calculated structural parameter and the porosity of training sets of pharmaceutical tablets, having well-defined characterization. Knowing of the structural arrangement, i.e. combined constituent skeletal-pore elements in series, parallel or mixed within porous media, could serve as a basis for understanding the ingress and permeation of liquids in such media. In the realm of pharmaceutical applications, such knowledge of the structural arrangement of air voids within a medicinal tablet could enable correlation with mechanical strength and dissolution behaviour in aqueous systems.Description
Keywords
Effective medium, Indomethacin, Microcrystalline cellulose, Microstructures, Pharmaceutical tablet, Terahertz
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Citation
Bawuah , P , Chakraborty , M , Ervasti , T , Zeitler , J A , Ketolainen , J , Gane , P A C & Peiponen , K-E 2016 , ' A structure parameter for porous pharmaceutical tablets obtained with the aid of Wiener bounds for effective permittivity and terahertz time-delay measurement ' , International Journal of Pharmaceutics , vol. 506 , no. 1-2 , pp. 87-92 . https://doi.org/10.1016/j.ijpharm.2016.04.026