All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2020-06-21
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Language
en
Pages
8
3270-3277
3270-3277
Series
Biomaterials Science, Volume 8, issue 12
Abstract
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.Description
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Citation
Costa, C, Liu, Z, Martins, J P, Correia, A, Figueiredo, P, Rahikkala, A, Li, W, Seitsonen, J, Ruokolainen, J, Hirvonen, S P, Aguiar-Ricardo, A, Corvo, M L & Santos, H A 2020, ' All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery ', Biomaterials Science, vol. 8, no. 12, pp. 3270-3277 . https://doi.org/10.1039/d0bm00743a
