Electrochemical and biological characterization of Ti–Nb–Zr–Si alloy for orthopedic applications

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorBordbar-Khiabani, Aydinen_US
dc.contributor.authorGasik, Michaelen_US
dc.contributor.departmentDepartment of Chemical and Metallurgical Engineeringen
dc.contributor.groupauthorMaterials Processing and Powder Metallurgyen
dc.date.accessioned2023-03-07T13:29:37Z
dc.date.available2023-03-07T13:29:37Z
dc.date.issued2023-02-09en_US
dc.description| openaire: EC/H2020/860462/EU//PREMUROSA Funding Information: Financial supports of the European Commission under FP6 SME integrated project “Meddelcoat” (contract 026501-2) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie ITN “Premurosa” (GA 860462) are gratefully acknowledged. Authors are greatly thankful for the late Dr. A. V. Mazur for help in TNZS alloy preparation, Dr. H. Yu for assistance in thermodynamic database optimization and Dr. D. Sukhomlinov for his help in performing the SEM/EDS. The LEMI assistance in analyzing details for the cells-materials interactions, led by Mrs. Prof. M.-F. Harmand and Mrs. D. Pierron, is also gratefully acknowledged. Publisher Copyright: © 2023, The Author(s).
dc.description.abstractThe performance of current biomedical titanium alloys is limited by inflammatory and severe inflammatory conditions after implantation. In this study, a novel Ti–Nb–Zr–Si (TNZS) alloy was developed and compared with commercially pure titanium, and Ti–6Al–4V alloy. Electrochemical parameters of specimens were monitored during 1 h and 12 h immersion in phosphate buffered saline (PBS) as a normal, PBS/hydrogen peroxide (H2O2) as an inflammatory, and PBS/H2O2/albumin/lactate as a severe inflammatory media. The results showed an effect of the H2O2 in inflammatory condition and the synergistic behavior of H2O2, albumin, and lactate in severe inflammatory condition towards decreasing the corrosion resistance of titanium biomaterials. Electrochemical tests revealed a superior corrosion resistance of the TNZS in all conditions due to the presence of silicide phases. The developed TNZS was tested for subsequent cell culture investigation to understand its biocompatibility nature. It exhibited favorable cell-materials interactions in vitro compared with Ti–6Al–4V. The results suggest that TNZS alloy might be a competitive biomaterial for orthopedic applications.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationBordbar-Khiabani, A & Gasik, M 2023, ' Electrochemical and biological characterization of Ti–Nb–Zr–Si alloy for orthopedic applications ', Scientific Reports, vol. 13, no. 1, 2312 . https://doi.org/10.1038/s41598-023-29553-5en
dc.identifier.doi10.1038/s41598-023-29553-5en_US
dc.identifier.issn2045-2322
dc.identifier.otherPURE UUID: 36e052a4-4b04-4405-849a-76c543df6314en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/36e052a4-4b04-4405-849a-76c543df6314en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85147792345&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/102101901/CHEM_Bordbar_Khiabani_and_Gasik_Electrochemical_and_biological_2023_Scientific_Reports.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/119993
dc.identifier.urnURN:NBN:fi:aalto-202303072321
dc.language.isoenen
dc.publisherNature Publishing Group
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/860462/EU//PREMUROSA Funding Information: Financial supports of the European Commission under FP6 SME integrated project “Meddelcoat” (contract 026501-2) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie ITN “Premurosa” (GA 860462) are gratefully acknowledged. Authors are greatly thankful for the late Dr. A. V. Mazur for help in TNZS alloy preparation, Dr. H. Yu for assistance in thermodynamic database optimization and Dr. D. Sukhomlinov for his help in performing the SEM/EDS. The LEMI assistance in analyzing details for the cells-materials interactions, led by Mrs. Prof. M.-F. Harmand and Mrs. D. Pierron, is also gratefully acknowledged. Publisher Copyright: © 2023, The Author(s).en_US
dc.relation.ispartofseriesScientific Reportsen
dc.relation.ispartofseriesVolume 13, issue 1en
dc.rightsopenAccessen
dc.titleElectrochemical and biological characterization of Ti–Nb–Zr–Si alloy for orthopedic applicationsen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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