Ultrasensitive Monolithic Dopamine Microsensors Employing Vertically Aligned Carbon Nanofibers
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2024-07-17
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Mcode
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en
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Advanced Healthcare Materials, Volume 13, issue 18
Abstract
Brain-on-Chip devices, which facilitate on-chip cultures of neurons to simulate brain functions, are receiving tremendous attention from both fundamental and clinical research. Consequently, microsensors are being developed to accomplish real-time monitoring of neurotransmitters, which are the benchmarks for neuron network operation. Among these, electrochemical sensors have emerged as promising candidates for detecting a critical neurotransmitter, dopamine. However, current state-of-the-art electrochemical dopamine sensors are suffering from issues like limited sensitivity and cumbersome fabrication. Here, a novel route in monolithically microfabricating vertically aligned carbon nanofiber electrochemical dopamine microsensors is reported with an anti-blistering slow cooling process. Thanks to the microfabrication process, microsensors is created with complete insulation and large surface areas. The champion device shows extremely high sensitivity of 4.52× 104 µAµM−1·cm−2, which is two-orders-of-magnitude higher than current devices, and a highly competitive limit of detection of 0.243 nM. These remarkable figures-of-merit will open new windows for applications such as electrochemical recording from a single neuron.Description
Publisher Copyright: © 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH. | openaire: EC/H2020/824070/EU//CONNECT
Keywords
atomic layer deposition, brain-on-chip, carbon nanofiber, microelectrodes, neurotransmitter
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Citation
Meng, L, Akhoundian, M, Al Azawi, A, Shoja, Y, Chi, P-Y, Meinander, K, Suihkonen, S & Franssila, S 2024, ' Ultrasensitive Monolithic Dopamine Microsensors Employing Vertically Aligned Carbon Nanofibers ', Advanced Healthcare Materials, vol. 13, no. 18, 2303872 . https://doi.org/10.1002/adhm.202303872