aalto1 untyped-item.component.html
Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation
Loading...
Access rights
openAccess
publishedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Unless otherwise stated, all rights belong to the author. You may download, display and print this publication for Your own personal use. Commercial use is prohibited.
Date
Major/Subject
Mcode
Degree programme
Language
en
Pages
4
Series
Frontiers in Cardiovascular Medicine, Volume 10, pp. 1-4
Abstract
We report here the first clinical use of the left atrial appendage (LAA) for epicardial micrograft transplantation during left ventricular assist device (LVAD) implantation. Previously, a sample from the right atrial appendage (RAA) has been available for processing and administering micrograft therapy in cardiac surgery. Both LAA and RAA are rich sources of various types of myocardial cells and are capable of providing both paracrine and cellular support to the failing myocardium. The surgical approach of LAA micrografting facilitates epicardial micrograft therapy dose escalation and treatment of larger myocardial areas than done previously. Moreover, as collection of treated vs. untreated tissues from the recipient heart is possible following LVAD implantation at the time of heart transplantation, the evaluation of the therapy's mechanism of action can be further deciphered at cellular and molecular levels. This LAA modification of the epicardial micrografting technique has the overall potential to facilitate the adoption of cardiac cell therapy during heart surgery.
Description
Funding Information: EpiHeart Oy and HBW srl contributed materials to this study. Open access funding was received from EpiHeart Oy. EpiHeart Oy were not involved in the study design, collection, analysis, interpretation of data, the writing of the article or the decision to submit it for publication. Publisher Copyright: 2023 Schmitto, Kuuva, Kronström, Hanke and Kankuri.
Other note
Citation
Schmitto, J D, Kuuva, A, Kronström, K, Hanke, J S & Kankuri, E 2023, 'Use of left atrial appendage as an autologous tissue source for epicardial micrograft transplantation during LVAD implantation', Frontiers in Cardiovascular Medicine, vol. 10, 1143886, pp. 1-4. https://doi.org/10.3389/fcvm.2023.1143886