Modeling and optimization of polyethylene glycol (PEG) addition for cost-efficient enzymatic hydrolysis of lignocellulose

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorPihlajaniemi, Villeen_US
dc.contributor.authorKallioinen, Anneen_US
dc.contributor.authorSipponen, Mikaen_US
dc.contributor.authorNyyssölä, Anttien_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorBioproduct Chemistryen
dc.date.accessioned2021-01-25T10:08:57Z
dc.date.available2021-01-25T10:08:57Z
dc.date.embargoinfo:eu-repo/date/embargoEnd/2022-12-26en_US
dc.date.issued2021-03en_US
dc.description.abstractEnzyme consumption is a key cost in the lignocellulosic sugar route for production of biofuels and chemicals, and polyethylene glycol (PEG) is a low-cost additive that improves hydrolysis efficiency. Despite many studies in this area, the relation of benefit over cost of PEG addition remains unclear. This article describes principles for expressing the effect of PEG as an equivalent enzyme amount, by merging PEG adsorption kinetics with a standardized enzyme dosage response. This model allows cost optimization of PEG addition by marginal analysis, as a function of enzyme dosage, solids concentration and price-ratio of enzyme and PEG. The model is based on the novel observations that the relative increase in apparent enzyme dosage by PEG addition is constant regardless of the absolute enzyme dosage, and that the increase correlates linearly with adsorption of PEG on hydrothermally pretreated wheat straw. The optimum ranged for most cases between 7 and 14 mg PEG per g substrate. The addition of PEG was attractive only above a threshold price-ratio, which decreased from 7.0–1.4 as enzyme dosage increased from 2 to 10 cost units per g substrate, showing that the incentive for introducing PEG to the process becomes stronger as the enzyme dosage increases.en
dc.description.versionPeer revieweden
dc.format.extent8
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationPihlajaniemi, V, Kallioinen, A, Sipponen, M & Nyyssölä, A 2021, ' Modeling and optimization of polyethylene glycol (PEG) addition for cost-efficient enzymatic hydrolysis of lignocellulose ', Biochemical Engineering Journal, vol. 167, 107894 . https://doi.org/10.1016/j.bej.2020.107894en
dc.identifier.doi10.1016/j.bej.2020.107894en_US
dc.identifier.issn1369-703X
dc.identifier.otherPURE UUID: 23b48a9d-eada-4ee0-9031-c66fc9fc0389en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/23b48a9d-eada-4ee0-9031-c66fc9fc0389en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85099118935&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/54774346/CHEM_Pihlajaniemi_et_al_Modeling_and_optimization_of_polyethylene_glycol_Biochemical_Engineering_Journal.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/102098
dc.identifier.urnURN:NBN:fi:aalto-202101251407
dc.language.isoenen
dc.publisherElsevier
dc.relation.ispartofseriesBIOCHEMICAL ENGINEERING JOURNALen
dc.relation.ispartofseriesVolume 167en
dc.rightsopenAccessen
dc.subject.keywordwheat strawen_US
dc.subject.keywordcellulaseen_US
dc.subject.keywordhydrolysis additiveen_US
dc.subject.keywordLangmuiren_US
dc.subject.keywordnonproductive bindingen_US
dc.subject.keywordmarginal benefiten_US
dc.titleModeling and optimization of polyethylene glycol (PEG) addition for cost-efficient enzymatic hydrolysis of lignocelluloseen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
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