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Probing the Immune System Dynamics of the COVID-19 Disease for Vaccine Designing and Drug Repurposing Using Bioinformatics Tools
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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Authors
Yadav, Deepshikha
Agarwal, Shriya
Pancham, Pranav
Jindal, Divya
Agarwal, Vinayak
Dubey, Premshankar Kumar
Jha, Saurabh K.
Mani, Shalini
Rachana
Dey, Abhijit
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en
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28
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Immuno, Volume 2, issue 2, pp. 344-371
Abstract
The pathogenesis of COVID-19 is complicated by immune dysfunction. The impact of immune-based therapy in COVID-19 patients has been well documented, with some notable studies on the use of anti-cytokine medicines. However, the complexity of disease phenotypes, patient heterogeneity and the varying quality of evidence from immunotherapy studies provide problems in clinical decision-making. This review seeks to aid therapeutic decision-making by giving an overview of the immunological responses against COVID-19 disease that may contribute to the severity of the disease. We have extensively discussed theranostic methods for COVID-19 detection. With advancements in technology, bioinformatics has taken studies to a higher level. The paper also discusses the application of bioinformatics and machine learning tools for the diagnosis, vaccine design and drug repurposing against SARS-CoV-2.
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Publisher Copyright: © 2022 by the authors.
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Yadav, D, Agarwal, S, Pancham, P, Jindal, D, Agarwal, V, Dubey, P K, Jha, S K, Mani, S, Rachana, Dey, A, Jha, N K, Kesari, K K & Singh, M 2022, 'Probing the Immune System Dynamics of the COVID-19 Disease for Vaccine Designing and Drug Repurposing Using Bioinformatics Tools', Immuno, vol. 2, no. 2, pp. 344-371. https://doi.org/10.3390/immuno2020022