Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorMarkl, Danielen_US
dc.contributor.authorWang, Parryen_US
dc.contributor.authorRidgway, Cathyen_US
dc.contributor.authorKarttunen, Anssi Pekkaen_US
dc.contributor.authorChakraborty, Mousumien_US
dc.contributor.authorBawuah, Princeen_US
dc.contributor.authorPääkkönen, Perttien_US
dc.contributor.authorGane, Patricken_US
dc.contributor.authorKetolainen, Jarkkoen_US
dc.contributor.authorPeiponen, Kai-Eriken_US
dc.contributor.authorZeitler, J. Axelen_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorPrinting Technologyen
dc.contributor.organizationUniversity of Cambridgeen_US
dc.contributor.organizationOmya International AGen_US
dc.contributor.organizationUniversity of Eastern Finlanden_US
dc.date.accessioned2019-05-06T09:05:33Z
dc.date.available2019-05-06T09:05:33Z
dc.date.issued2017-05en_US
dc.description.abstractNovel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45%-65% were prepared in 5% steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R 2 = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance.en
dc.description.versionPeer revieweden
dc.format.extent1586–1595
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationMarkl, D, Wang, P, Ridgway, C, Karttunen, A P, Chakraborty, M, Bawuah, P, Pääkkönen, P, Gane, P, Ketolainen, J, Peiponen, K-E & Zeitler, J A 2017, ' Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography ', Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1586–1595 . https://doi.org/10.1016/j.xphs.2017.02.028en
dc.identifier.doi10.1016/j.xphs.2017.02.028en_US
dc.identifier.issn0022-3549
dc.identifier.issn1520-6017
dc.identifier.otherPURE UUID: 0bdb0ac4-1a30-434e-97e6-6e3987f40150en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/0bdb0ac4-1a30-434e-97e6-6e3987f40150en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85017391273&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/32889923/1_s2.0_S0022354917301430_main.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/37598
dc.identifier.urnURN:NBN:fi:aalto-201905062718
dc.language.isoenen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofseriesJournal of Pharmaceutical Sciencesen
dc.relation.ispartofseriesVolume 106, issue 6en
dc.rightsopenAccessen
dc.subject.keywordImaging methodsen_US
dc.subject.keywordMathematical modelsen_US
dc.subject.keywordMechanical propertiesen_US
dc.subject.keywordPhysical characterizationen_US
dc.subject.keywordRefractive indexen_US
dc.subject.keywordSolid dosage formen_US
dc.subject.keywordSpectroscopyen_US
dc.titleCharacterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomographyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
Files