Synthesis of an Azide-and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorGulumkar, Vijayen_US
dc.contributor.authorTähtinen, Villeen_US
dc.contributor.authorAli, Aliaaen_US
dc.contributor.authorRahkila, Janien_US
dc.contributor.authorValle-Delgado, Juan Joséen_US
dc.contributor.authorÄärelä, Anttien_US
dc.contributor.authorÖsterberg, Monikaen_US
dc.contributor.authorYliperttula, Marjoen_US
dc.contributor.authorVirta, Pasien_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorBioproduct Chemistryen
dc.contributor.organizationUniversity of Turkuen_US
dc.contributor.organizationÅbo Akademi Universityen_US
dc.contributor.organizationUniversity of Helsinkien_US
dc.date.accessioned2022-01-26T07:46:32Z
dc.date.available2022-01-26T07:46:32Z
dc.date.issued2022-01-11en_US
dc.descriptionFunding Information: V.G. and P.V. acknowledge Academy of Finland’s Project No. 308931. J.J.V.D. and M.Ö. acknowledge Academy of Finland’s Flagship Programme under Project Nos. 318890 and 318891 (Competence Center for Materials Bioeconomy, FinnCERES). M.Y. acknowledges Academy of Finland’s Flagship Programme under Project No. 337430 (Gene, Cell and Nano Therapy Competence Cluster for the Treatment of Chronic Diseases, GeneCellNano). Publisher Copyright: © 2021 The Authors. Published by American Chemical Society.
dc.description.abstractBingel cyclopropanation between Buckminster fullerene and a heteroarmed malonate was utilized to produce a hexakis-functionalized C60 core, with azide and tetrazine units. This orthogonally bifunctional C60 scaffold can be selectively one-pot functionalized by two pericyclic click reactions, that is, inverse electron-demand Diels-Alder and azide-alkyne cycloaddition, which with appropriate ligands (monosaccharides, a peptide and oligonucleotides tested) allows one to control the assembly of heteroantennary bioconjugates.en
dc.description.versionPeer revieweden
dc.format.extent1329–1336
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationGulumkar, V, Tähtinen, V, Ali, A, Rahkila, J, Valle-Delgado, J J, Äärelä, A, Österberg, M, Yliperttula, M & Virta, P 2022, ' Synthesis of an Azide-and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules ', ACS Omega, vol. 7, no. 1, pp. 1329–1336 . https://doi.org/10.1021/acsomega.1c05955en
dc.identifier.doi10.1021/acsomega.1c05955en_US
dc.identifier.issn2470-1343
dc.identifier.otherPURE UUID: 16820d56-d11a-4b99-9e3b-6f3ec1176207en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/16820d56-d11a-4b99-9e3b-6f3ec1176207en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85122739024&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/78625888/CHEM_Gulumkar_et_al_Synthesis_of_an_Azide_and_Tetrazine_Functionalized_2022_ACS_Omega.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/112512
dc.identifier.urnURN:NBN:fi:aalto-202201261413
dc.language.isoenen
dc.publisherAMERICAN CHEMICAL SOCIETY
dc.relation.ispartofseriesACS Omegaen
dc.relation.ispartofseriesVolume 7, issue 1en
dc.rightsopenAccessen
dc.titleSynthesis of an Azide-and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomoleculesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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