TMS and EEG in the study of human brain dynamics

Thumbnail Image

Files

isbn9789526406787.pdf (1.82 MB)

URL

Journal Title

Journal ISSN

Volume Title

School of Science | Doctoral thesis (article-based) | Defence date: 2022-02-04
Unless otherwise stated, all rights belong to the author. You may download, display and print this publication for Your own personal use. Commercial use is prohibited.

Authors

Date

2022

Department

Neurotieteen ja lääketieteellisen tekniikan laitos
Department of Neuroscience and Biomedical Engineering

Major/Subject

Mcode

Degree programme

Language

en

Pages

61 + app. 77

Series

Aalto University publication series DOCTORAL THESES, 13/2022

Abstract

The studies that comprise the basis of this Thesis intended to detect specific brain responses, known as event-related potentials (ERP), and changes in the cortical rhythms through the utilization of electroencephalography (EEG). In addition, transcranial magnetic stimulation (mTMS) was performed with a multichannel transducer to evaluate cortical excitability and connectivity for many locations and orientations. The results revealed novel aspects of the functioning network of the brain. Study I proves that detection of deviant visual stimuli is possible based on the amplitude modulation of the α-band oscillations. This was manifested in deviant stimuli inducing stronger synchronization and desynchronization of the α-rhythm, as compared to standard stimuli.Study II presents the principles of the electric field (E-field) electronic rotation using an mTMS transducer. The study quantifies the role of the E-field orientation for neuronal activation through the changes of amplitude and latencies in motor evoked potentials (MEP) recorded from hand muscles. The sensitivity of specific neuronal populations to the E-field orientation was demonstrated based on changes in inhibition and facilitation of the amplitude of MEP induced by different orientations of the stimulus during paired-pulse stimulation. Studies III and IV investigate the role of conditioning and test stimuli in short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), and short-interval intracortical facilitation (SICF). The studies show that the sensitivity of these phenomena depends on mechanisms related to specific stimulus intensities, orientations, and interstimulus intervals. Finally, Study V explores the role of the E-field orientation in generating mismatch negativity (MMN)-like responses. Stimulation of the same area of the motor cortex with slightly differently oriented stimuli resulted in stronger brain responses induced by rare deviant stimulus than by standard stimulus. The presence of TMS-induced MMN suggests that the brain has the ability to automatically detect deviant stimuli. Due to technical limitations, Study V has not been published. This Thesis introduces novel methods and instrumentation for human brain investigation. The results demonstrate that these methods can elucidate new aspects of brain functioning, allowing for their further application in contemporary scientific research and clinical practice.

Description

Defence is held on 4.2.2022 12:00 – 16:00 (Zoom), https://aalto.zoom.us/j/68863302627

Supervising professor

Ilmoniemi, Risto, Prof., Aalto University, Department of Neuroscience and Biomedical Engineering, Finland

Thesis advisor

Nikulin, Vadim V., Dr., Max Planck Institute for Human Cognitive and Brain Sciences, Germany
Hernandez Pavon, Julio C. , Dr., Northwestern University/Shirley Ryan AbilityLab, USA
Lioumis, Pantelis, Dr., Aalto University, Finland

Keywords

transcranial magnetic stimulation, electroencephalography, motor evoked potentials, mismatch negativity, short-interval intracortical inhibition

Other note

Parts

  • [Publication 1]: Tugin S, Hernandez-Pavon J, Ilmoniemi RJ, Nikulin VV. Visual deviant stimuli produce mismatch responses in the amplitude dynamics of neuronal oscillations. NeuroImage, 142: 645–655, 2016.
    DOI: 10.1016/j.neuroimage.2016.07.024 View at publisher
  • [Publication 2]: Souza VH, Nieminen JO, Tugin S, Koponen L, Baffa O, Ilmoniemi RJ. Fine multi-coil electronic control of transcranial magnetic stimulation: effects of stimulus orientation and intensity. bioRxiv. 2021. https://www.biorxiv.org/content/early/2021/08/23/2021.08.20.457101
  • [Publication 3]: Souza VH, Nieminen JO, Tugin S, Koponen L, Baffa O, Ilmoniemi RJ. Probing the orientation specificity of excitatory and inhibitory circuitries in the primary motor cortex with multi-channel TMS. bioRxiv. 2021.
    DOI: 10.1101/2021.08.20.457101 View at publisher
  • [Publication 4]: Tugin S, Souza VH, Nazarova NA, Novikov PA, Tervo AE, Nieminen JO, Lioumis P, Nikulin VV, Ziemann U, Ilmoniemi RJ. Effect of stimulus orientation and intensity on short-interval intracortical inhibition (SICI) and facilitation (SICF): a multi-channel transcranial magnetic stimulation study. PlosOne, 16(9): e0257554, 2021.
    Full text in Acris/Aaltodoc: http://urn.fi/URN:NBN:fi:aalto-202111019895
    DOI: 10.1371/journal.pone.0257554 View at publisher

Citation

Permanent link to this item

https://urn.fi/URN:ISBN:978-952-64-0678-7

Collections

[diss] Perustieteiden korkeakoulu / SCI