Understanding lignin aggregation processes. A case study: Budesonide entrapment and stimuli controlled release from lignin nanoparticles
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2018
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en
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9342-9351
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ACS Sustainable Chemistry and Engineering, Volume 6, issue 7
Abstract
The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation-growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide, but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.Description
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Sipponen, M H, Lange, H, Ago, M & Crestini, C 2018, ' Understanding lignin aggregation processes. A case study : Budesonide entrapment and stimuli controlled release from lignin nanoparticles ', ACS Sustainable Chemistry and Engineering, vol. 6, no. 7, pp. 9342-9351 . https://doi.org/10.1021/acssuschemeng.8b01652