Ultrasensitive Mid-Infrared Biosensing in Aqueous Solutions with Graphene Plasmons

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorWu, Chenchenen_US
dc.contributor.authorGuo, Xiangdongen_US
dc.contributor.authorDuan, Yuen_US
dc.contributor.authorLyu, Weien_US
dc.contributor.authorHu, Haien_US
dc.contributor.authorHu, Deboen_US
dc.contributor.authorChen, Keen_US
dc.contributor.authorSun, Zhipeien_US
dc.contributor.authorGao, Tengen_US
dc.contributor.authorYang, Xiaoxiaen_US
dc.contributor.authorDai, Qingen_US
dc.contributor.departmentDepartment of Electronics and Nanoengineeringen
dc.contributor.groupauthorCentre of Excellence in Quantum Technology, QTFen
dc.contributor.groupauthorZhipei Sun Groupen
dc.contributor.organizationNational Center for Nanoscience and Technology Beijingen_US
dc.date.accessioned2022-06-15T06:40:09Z
dc.date.available2022-06-15T06:40:09Z
dc.date.embargoinfo:eu-repo/date/embargoEnd/2023-04-23en_US
dc.date.issued2022-07-07en_US
dc.description| openaire: EC/H2020/820423/EU//S2QUIP | openaire: EC/H2020/965124/EU//FEMTOCHIP | openaire: EC/H2020/834742/EU//ATOP
dc.description.abstractIdentifying nanoscale biomolecules in aqueous solutions by Fourier transform infrared spectroscopy (FTIR) provides an in situ and noninvasive method for exploring the structure, reactions, and transport of biologically active molecules. However, this remains a challenge due to the strong and broad IR absorption of water which overwhelms the respective vibrational fingerprints of the biomolecules. In this work, a tunable IR transparent microfluidic system with graphene plasmons is exploited to identify approximate to 2 nm-thick proteins in physiological conditions. The acquired in situ tunability makes it possible to eliminate the IR absorption of water outside the graphene plasmonic hotspots by background subtraction. Most importantly, the ultrahigh confinement of graphene plasmons (confined to approximate to 15 nm) permits the implementation of nanoscale sensitivity. Then, the deuterium effects on monolayer proteins are characterized within an aqueous solution. The tunable graphene-plasmon-enhanced FTIR technology provides a novel platform for studying biological processes in an aqueous solution at the nanoscale.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationWu, C, Guo, X, Duan, Y, Lyu, W, Hu, H, Hu, D, Chen, K, Sun, Z, Gao, T, Yang, X & Dai, Q 2022, ' Ultrasensitive Mid-Infrared Biosensing in Aqueous Solutions with Graphene Plasmons ', Advanced Materials, vol. 34, no. 27, 2110525 . https://doi.org/10.1002/adma.202110525en
dc.identifier.doi10.1002/adma.202110525en_US
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.otherPURE UUID: c3ae1220-64ad-49a6-bef3-b6893a3d1b36en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/c3ae1220-64ad-49a6-bef3-b6893a3d1b36en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85130773720&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/84500285/Wu_Ultrasensitive_mid_infrared_biosensing.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/114982
dc.identifier.urnURN:NBN:fi:aalto-202206153824
dc.language.isoenen
dc.publisherWILEY-V C H VERLAG GMBH
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/834742/EU//ATOPen_US
dc.relation.ispartofseriesAdvanced Materialsen
dc.rightsopenAccessen
dc.subject.keywordaqueous solutionsen_US
dc.subject.keywordbiosensingen_US
dc.subject.keywordgraphene plasmonsen_US
dc.subject.keywordsurface-enhanced infrared spectroscopyen_US
dc.titleUltrasensitive Mid-Infrared Biosensing in Aqueous Solutions with Graphene Plasmonsen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi

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