Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorCosta, M. M.
dc.contributor.authorLima, R.
dc.contributor.authorAlves, N.
dc.contributor.authorSilva, N. A.
dc.contributor.authorGasik, M.
dc.contributor.authorSilva, F. S.
dc.contributor.authorBartolomeu, F.
dc.contributor.authorMiranda, G.
dc.contributor.departmentUniversity of Minho
dc.contributor.departmentPolytechnic Institute of Leiria
dc.contributor.departmentMaterials Processing and Powder Metallurgy
dc.contributor.departmentUniversity of Aveiro
dc.contributor.departmentDepartment of Chemical and Metallurgical Engineeringen
dc.date.accessioned2022-10-26T06:28:02Z
dc.date.available2022-10-26T06:28:02Z
dc.date.issued2022-07
dc.descriptionFunding Information: This work was supported by FCT (Fundação para a Ciência e a Tecnologia) through the grant SFRH/BD/140191/2018 , the work contract CEECIND/04794/2007 , the project PTDC/EME-EME/1442/2020 (Add2MechBio) and the project NORTE-01-0145-FEDER-029968 . This work has been also funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI - Portuguese Platform of Bioimaging ( PPBI–POCI-01-0145-FEDER-022122 ). Additionally, it was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 , UIDP/50011/2020 & LA/P/0006/2020 , financed by national funds through the FCT/MEC (PIDDAC). Finally, this work was supported by FCT national funds, under the national support to R&D units grant, through the reference projects UIDB/04436/2020 , UIDP/04436/2020 , UIDB/50026/2020 and UIDP/50026/2020 . Publisher Copyright: © 2022 Elsevier Ltd
dc.description.abstractIn this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance.en
dc.description.versionPeer revieweden
dc.format.extent16
dc.format.mimetypeapplication/pdf
dc.identifier.citationCosta , M M , Lima , R , Alves , N , Silva , N A , Gasik , M , Silva , F S , Bartolomeu , F & Miranda , G 2022 , ' Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance ' , Journal of the Mechanical Behavior of Biomedical Materials , vol. 131 , 105246 . https://doi.org/10.1016/j.jmbbm.2022.105246en
dc.identifier.doi10.1016/j.jmbbm.2022.105246
dc.identifier.issn1751-6161
dc.identifier.issn1878-0180
dc.identifier.otherPURE UUID: 57f7bc65-d98d-4331-b58b-fdee625b0cb3
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/57f7bc65-d98d-4331-b58b-fdee625b0cb3
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85129173382&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/90309608/CHEM_Costa_et_al_Multi_material_cellular_2022_J_Mech_Behav_Biomed_Mater.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/117458
dc.identifier.urnURN:NBN:fi:aalto-202210266240
dc.language.isoenen
dc.publisherElsevier Science B.V.
dc.relation.ispartofseriesJournal of the Mechanical Behavior of Biomedical Materialsen
dc.relation.ispartofseriesVolume 131en
dc.rightsopenAccessen
dc.subject.keywordBio-tribological experiments
dc.subject.keywordIn vitro
dc.subject.keywordMulti-material structures
dc.subject.keywordNiTi-Based
dc.subject.keywordTi6Al4V-based
dc.titleMulti-material cellular structured orthopedic implants design: In vitro and bio-tribological performanceen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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