Chemoenzymatic Total Synthesis of (+)- & (−)-cis-Osmundalactone

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorBlume, Fabianen_US
dc.contributor.authorLiu, Yu-Changen_US
dc.contributor.authorThiel, Danielen_US
dc.contributor.authorDeska, Janen_US
dc.contributor.departmentDepartment of Chemistry and Materials Scienceen
dc.contributor.departmentDepartment of Chemistryen
dc.contributor.groupauthorBioorganic chemistryen
dc.date.accessioned2017-03-23T12:48:48Z
dc.date.available2017-03-23T12:48:48Z
dc.date.embargoinfo:eu-repo/date/embargoEnd/2018-11-11en_US
dc.date.issued2016-11-12en_US
dc.description.abstractBoth optical antipodes of the cis-isomers of osmundalactone, a hydroxypyranone natural product and core structure of the angiopterlactones, have been synthesized from acetylfuran in only three steps through a redox cascade utilizing oxidoreductases and transition metal catalysis in a concerted fashion. The key step in this fully catalytic strategy is the enzyme-mediated Achmatowicz reaction via selective furan oxygenation to furnish the pyran core structure.en
dc.description.versionPeer revieweden
dc.format.extent5
dc.format.extent280-284
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationBlume, F, Liu, Y-C, Thiel, D & Deska, J 2016, ' Chemoenzymatic Total Synthesis of (+)- & (−)-cis-Osmundalactone ', Journal of Molecular Catalysis B: Enzymatic, vol. 134, pp. 280-284 . https://doi.org/10.1016/j.molcatb.2016.11.010en
dc.identifier.doi10.1016/j.molcatb.2016.11.010en_US
dc.identifier.issn1381-1177
dc.identifier.issn1873-3158
dc.identifier.otherPURE UUID: d1b4fb3c-c444-4869-bf74-10774e2af542en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/d1b4fb3c-c444-4869-bf74-10774e2af542en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/11163596/JMCBE2016.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/24947
dc.identifier.urnURN:NBN:fi:aalto-201703233190
dc.language.isoenen
dc.relation.ispartofseriesJOURNAL OF MOLECULAR CATALYSIS B: ENZYMATICen
dc.relation.ispartofseriesVolume 134en
dc.rightsopenAccessen
dc.subject.keywordbiocatalysisen_US
dc.subject.keywordnatural productsen_US
dc.subject.keywordperoxidaseen_US
dc.subject.keywordDEHYDROGENASEen_US
dc.subject.keywordoxidative rearrangementen_US
dc.subject.keywordchemoenzymaticen_US
dc.titleChemoenzymatic Total Synthesis of (+)- & (−)-cis-Osmundalactoneen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi

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[article-cris] Kemian tekniikan korkeakoulu / CHEM