Chemoenzymatic Total Synthesis of (+)- & (−)-cis-Osmundalactone
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2016-11-12
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Language
en
Pages
5
280-284
280-284
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JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, Volume 134
Abstract
Both optical antipodes of the cis-isomers of osmundalactone, a hydroxypyranone natural product and core structure of the angiopterlactones, have been synthesized from acetylfuran in only three steps through a redox cascade utilizing oxidoreductases and transition metal catalysis in a concerted fashion. The key step in this fully catalytic strategy is the enzyme-mediated Achmatowicz reaction via selective furan oxygenation to furnish the pyran core structure.Description
Keywords
biocatalysis, natural products, peroxidase, DEHYDROGENASE, oxidative rearrangement, chemoenzymatic
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Citation
Blume, F, Liu, Y-C, Thiel, D & Deska, J 2016, ' Chemoenzymatic Total Synthesis of (+)- & (−)-cis-Osmundalactone ', Journal of Molecular Catalysis B: Enzymatic, vol. 134, pp. 280-284 . https://doi.org/10.1016/j.molcatb.2016.11.010