Biological activity of multicomponent bio-hydrogels loaded with tragacanth gum

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-08-31
Major/Subject
Mcode
Degree programme
Language
en
Pages
14
691-704
Series
International Journal of Biological Macromolecules, Volume 215
Abstract
Producing hydrogels capable of mimicking the biomechanics of soft tissue remains a challenge. We explore the potential of plant-based hydrogels as polysaccharide tragacanth gum and antioxidant lignin nanoparticles in bioactive multicomponent hydrogels for tissue engineering. These natural components are combined with TEMPO-oxidized cellulose nanofibrils, a material with known shear thinning behavior. Hydrogels presented tragacanth gum (TG) concentration-dependent rheological properties suitable for extrusion 3D printing. TG enhanced the swelling capacity up to 645% and the degradation rate up to 1.3%/day for hydrogels containing 75% of TG. Young's moduli of the hydrogels varied from 5.0 to 11.6 kPa and were comparable to soft tissues like skin and muscle. In vitro cell viability assays revealed that the scaffolds were non-toxic and promoted proliferation of hepatocellular carcinoma HepG2 cells. Therefore, the plant-based hydrogels designed in this work have a significant potential for tissue engineering.
Description
Keywords
Tragacanth gum, Hydrogels, Cellulose nanofibrils, Lignin nanoparticles (LNP), Bioprinting, Tissue engineering
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Citation
Teixeira Polez, R, Morits, M, Jonkergouw, C, Phiri, J, Valle-Delgado, J J, Seppälä, J, Linder, M B, Maloney, T, Rojas Gaona, O & Österberg, M 2022, ' Biological activity of multicomponent bio-hydrogels loaded with tragacanth gum ', International Journal of Biological Macromolecules, vol. 215, pp. 691-704 . https://doi.org/10.1016/j.ijbiomac.2022.06.153