aalto1 untyped-item.component.html
Monitoring and controlling of recombinant protein production with Pichia pastoris
Loading...
Files
Aalto login required (access for Aalto Staff only).
URL
Journal Title
Journal ISSN
Volume Title
Kemiantekniikan korkeakoulu |
Bachelor's thesis
Electronic archive copy is available locally at the Harald Herlin Learning Centre. The staff of Aalto University has access to the electronic bachelor's theses by logging into Aaltodoc with their personal Aalto user ID. Read more about the availability of the bachelor's theses.
Unless otherwise stated, all rights belong to the author. You may download, display and print this publication for Your own personal use. Commercial use is prohibited.
Authors
Date
Department
Major/Subject
Mcode
CHEM3054
Degree programme
Language
en
Pages
29+5
Series
Abstract
Proteins and peptides are the fundamental of the biopharmaceutical industry. Hundreds of drug products from them are currently circulated on the market, and many are under clinical trials. However, the complexity of proteins structure and function creates difficult for developing a new product or improving existing ones. Therefore, recombinant proteins, synthesised in a microorganism host cell, attract the attention of the industry because of their high yields and simplicity in the production process. Fermentation strategies are constantly reviewed and adjusted to maintain optimal conditions for maximum productivity and quality while minimising disadvantaged factors. This paper discusses in detail Pichia pastoris host system and different strategies to monitor and control the production process.