Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorRäisänen, Katien_US
dc.contributor.authorKoivula, Irmaen_US
dc.contributor.authorIlmavirta, Heikkien_US
dc.contributor.authorPuranen, Santerien_US
dc.contributor.authorKallonen, Teemuen_US
dc.contributor.authorLyytikäinen, Outien_US
dc.contributor.authorJalava, Jarien_US
dc.contributor.departmentDepartment of Computer Scienceen
dc.contributor.groupauthorHelsinki Institute for Information Technology (HIIT)en
dc.contributor.groupauthorProfessorship Kaski Samuelen
dc.contributor.organizationFinnish Institute for Health and Welfare (THL)en_US
dc.contributor.organizationUniversity of Eastern Finlanden_US
dc.date.accessioned2019-07-30T07:14:44Z
dc.date.available2019-07-30T07:14:44Z
dc.date.issued2019-05-01en_US
dc.description.abstractIn December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing Klebsiella pneumoniae strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with blaKPC-2-producing K. pneumoniae ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site.en
dc.description.versionPeer revieweden
dc.format.extent3
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationRäisänen, K, Koivula, I, Ilmavirta, H, Puranen, S, Kallonen, T, Lyytikäinen, O & Jalava, J 2019, 'Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018', Eurosurveillance, vol. 24, no. 19, pp. 1-3. https://doi.org/10.2807/1560-7917.ES.2019.24.19.1900256en
dc.identifier.doi10.2807/1560-7917.ES.2019.24.19.1900256en_US
dc.identifier.issn1025-496X
dc.identifier.issn1560-7917
dc.identifier.otherPURE UUID: 1d1c397d-0a0f-485d-9dcc-5d7b745a6176en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/1d1c397d-0a0f-485d-9dcc-5d7b745a6176en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/35132945/eurosurv_24_19_1.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/39397
dc.identifier.urnURN:NBN:fi:aalto-201907304452
dc.language.isoenen
dc.publisherEuropean Centre for Disease Prevention and Control (ECDC)
dc.relation.ispartofseriesEurosurveillanceen
dc.relation.ispartofseriesVolume 24, issue 19, pp. 1-3en
dc.rightsopenAccessen
dc.subject.keywordcarbapenemen_US
dc.subject.keywordceftazidime-avibactamen_US
dc.subject.keywordKlebsiella pneumoniaeen_US
dc.subject.keywordresistanceen_US
dc.subject.keywordwhole-genome sequencing, KPC-2en_US
dc.titleEmergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018en
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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