Seasonal variation of diarrhoeal pathogens among Guinea-Bissauan children under five years of age

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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PLoS Neglected Tropical Diseases, Volume 17, issue 3
Background: Diarrhoea remains a major cause of childhood morbidity and mortality in low-income countries (LICs). The frequency of diarrhoeal episodes may vary by season, yet few prospective cohort studies have examined seasonal variation among various diarrhoeal pathogens using multiplex qPCR to analyse bacterial, viral and parasitic pathogens. Methods: We combined our recent qPCR data of diarrhoeal pathogens (nine bacterial, five viral and four parasitic) among Guinea-Bissauan children under five years old with individual background data, dividing by season. The associations of season (dry winter and rainy summer) and the various pathogens were explored among infants (0–11 months) and young children (12–59 months) and those with and without diarrhoea. Results: Many bacterial pathogens, especially EAEC, ETEC and Campylobacter, and parasitic Cryp-tosporidium, prevailed in the rainy season, whereas many viruses, particularly the adenovi-rus, astrovirus and rotavirus proved common in the dry season. Noroviruses were found constantly throughout the year. Seasonal variation was observed in both age groups. Conclusion: In childhood diarrhoea in a West African LIC, seasonal variation appears to favour EAEC, ETEC, and Cryptosporidium in the rainy and viral pathogens in the dry season.
Funding Information: This work was supported by the Finnish Governmental Subsidy for Health Science Research, (AK), the Scandinavian Society for Antimicrobial Chemotherapy Foundation, https:// (AK), the Sigrid Jusélius Foundation, (AK), the University of Helsinki Doctoral School on Health Science, doctoral-schools-and-doctoral-programmes/ doctoral-school health-sciences (SM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2023 Mero et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mero , S , Lääveri , T , Ursing , J , Rombo , L , Kofoed , P E & Kantele , A 2023 , ' Seasonal variation of diarrhoeal pathogens among Guinea-Bissauan children under five years of age ' , PLoS Neglected Tropical Diseases , vol. 17 , no. 3 , e0011179 , pp. 1-16 .