Release of model drugs with different solubilities from polylactone based degradable polymer matrices
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School of Chemical Engineering |
Master's thesis
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Date
2012
Department
Major/Subject
Polymeeriteknologia
Mcode
Kem-100
Degree programme
Language
en
Pages
vii + 90 s. + liitt. 34
Series
Abstract
The aim of this thesis was to study the effect on the release profile of E-caprolactone and L-lactide based polymeric drug delivery devices when active agents of different solubility were used. Both long-acting and short-acting polymeric drug delivery devices for controlled drug delivery were studied. For the thesis, the release of three different active agents from two different polymer families was studied in aqueous buffer solution at pH 7.4 and temperature 37°C. Surface eroding poly(ester-anhydride) samples were prepared by crosslinking functionalised poly(E-caprolactone) precursors, while diffusion controlled the poly(ester) samples were synthesized by ring-opening polymerisation of E-caprolactone and L-lactide. Two different molar ratios were used for the copolymers. As active agent's propranolol HCI, amlodipine maleate, and itraconazole were used. All samples had a 10 m-% drug loading. The release rate of poly(ester anhydride) samples was linearly related to the erosion rate. The erosion rate for the samples clearly depended on the hydrophilicity of the active agent so that the most hydrophobic active agent had the slowest degradation time. All samples degraded in 20 to 35 hours. In the thermoplastic copolymers, a higher amount of lactide in the copolymer led to a higher release rate. The difference in release rate due to the molar ratio was most prominent when the active agent was highly hydrophilic. Depending on the polymer and the active agent, 20 to 100 % of the initial active agent was released during 11 weeks. This work contributed to the understanding of degradable polymers as drug delivery devices. Further studies are still needed before the studied materials can be applied for clinical usage. Also the effect of the testing procedure should be further explored.Description
Supervisor
Seppälä, JukkaThesis advisor
Korhonen, HarriHakala, Risto
Keywords
controlled drug delivery, kontrollerad läkemedelsfrigöring, polyester anhydride, polyester anhydrid, poly e-caprolactone-co-lactide, poly e-kaprolakton-co-laktid