Task- and stimulus-related cortical networks in language production: Exploring similarity of MEG- and fMRI-derived functional connectivity

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorLiljeström, Miaen_US
dc.contributor.authorStevenson, Claireen_US
dc.contributor.authorKujala, Janen_US
dc.contributor.authorSalmelin, Riittaen_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.date.accessioned2017-05-11T09:14:43Z
dc.date.available2017-05-11T09:14:43Z
dc.date.issued2015-10en_US
dc.description.abstractLarge-scale networks support the dynamic integration of information across multiple functionally specialized brain regions. Network analyses of haemodynamic modulations have revealed such functional brain networks that show high consistency across subjects and different cognitive states. However, the relationship between the slowly fluctuating haemodynamic responses and the underlying neural mechanisms is not well understood. Resting state studies have revealed spatial similarities in the estimated network hub locations derived using haemodynamic and electrophysiological recordings, suggesting a direct neural basis for the widely described functional magnetic resonance imaging (fMRI) resting state networks. To truly understand the nature of the relationship between electrophysiology and haemodynamics it is important to move away from a task absent state and to establish if such networks are differentially modulated by cognitive processing. The present parallel fMRI and magnetoencephalography (MEG) experiment investigated the structural similarities between haemodynamic networks and their electrophysiological counterparts when either the stimulus or the task was varied. Connectivity patterns underlying action vs. object naming (task-driven modulations), and action vs. object images (stimulus-driven modulations) were identified in a data driven all-to-all connectivity analysis, with cross spectral coherence adopted as a metric of functional connectivity in both MEG and fMRI. We observed a striking difference in functional connectivity between conditions. The spectral profiles of the frequency-specific network similarity differed significantly for the task-driven vs. stimulus-driven connectivity modulations. While the greatest similarity between MEG and fMRI derived networks was observed at neural frequencies below 30 Hz, haemodynamic network interactions could not be attributed to a single frequency band. Instead, the entire spectral profile should be taken into account when assessing the correspondence between MEG and fMRI networks. Task-driven network hubs, evident in both MEG and fMRI, were found in cortical regions previously associated with language processing, including the posterior temporal cortex and the inferior frontal cortex. Network hubs related to stimulus-driven modulations, however, were found in regions related to object recognition and visual processing, including the lateral occipital cortex. Overall, the results depict a shift in network structure when moving from a task dependent modulation to a stimulus dependent modulation, revealing a reorganization of large-scale functional connectivity during task performance.en
dc.description.versionPeer revieweden
dc.format.extent13
dc.format.extent75-87
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationLiljeström, M, Stevenson, C, Kujala, J & Salmelin, R 2015, ' Task- and stimulus-related cortical networks in language production: Exploring similarity of MEG- and fMRI-derived functional connectivity ', NeuroImage, vol. 120, pp. 75-87 . https://doi.org/10.1016/j.neuroimage.2015.07.017en
dc.identifier.doi10.1016/j.neuroimage.2015.07.017en_US
dc.identifier.issn1053-8119
dc.identifier.issn1095-9572
dc.identifier.otherPURE UUID: eec12e77-f662-42c9-9047-ab55299c101ben_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/eec12e77-f662-42c9-9047-ab55299c101ben_US
dc.identifier.otherPURE LINK: http://dx.doi.org/10.1016/j.neuroimage.2015.07.017en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/11702038/1_s2.0_S1053811915006266_main.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/25954
dc.identifier.urnURN:NBN:fi:aalto-201705114329
dc.language.isoenen
dc.relation.ispartofseriesNEUROIMAGEen
dc.relation.ispartofseriesVolume 120en
dc.rightsopenAccessen
dc.subject.keywordMEGen_US
dc.subject.keywordfMRIen_US
dc.subject.keywordFunctional connectivityen_US
dc.subject.keywordConnectomeen_US
dc.subject.keywordTask networksen_US
dc.subject.keywordPicture namingen_US
dc.titleTask- and stimulus-related cortical networks in language production: Exploring similarity of MEG- and fMRI-derived functional connectivityen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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