Alterations in Microstructure and Local Fiber Orientation of White Matter Are Associated with Outcome after Mild Traumatic Brain Injury
No Thumbnail Available
Access rights
openAccess
acceptedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
Date
2020-12-15
Major/Subject
Mcode
Degree programme
Language
en
Pages
8
Series
Journal of Neurotrauma, Volume 37, issue 24, pp. 2616-2623
Abstract
Mild traumatic brain injury (mTBI) can have long-lasting consequences. We investigated white matter (WM) alterations at 6-12 months following mTBI using diffusion tensor imaging (DTI) and assessed if the alterations associate with outcome. Eighty-five patients with mTBI underwent diffusion-weighted magnetic resonance imaging (MRI) on average 8 months post-injury and patients' outcome was assessed at the time of imaging using the Glasgow Outcome Scale-Extended (GOS-E). Additionally, 30 age-matched patients with extracranial orthopedic injuries were used as control subjects. Voxel-wise analysis of the data was performed using a tract-based spatial statistics (TBSS) approach and differences in microstructural metrics between groups were investigated. Further, the susceptibility of the abnormalities to specific fiber orientations was investigated by analyzing the first eigenvector of the diffusion tensor in the voxels with significant differences. We found significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) and radial diffusivity (RD) in patients with mTBI compared with control subjects, whereas no significant differences were observed in axial diffusivity (AD) between the groups. The differences were present bilaterally in several WM regions and correlated with outcome. Moreover, multiple clusters were found in the principal fiber orientations of the significant voxels in anisotropy, and similar orientation patterns were found for the diffusivity metrics. These directional clusters correlated with patients' functional outcome. Our study showed that mTBI is associated with WM changes at the chronic stage and these alterations occur in several WM regions. In addition, several significant clusters of WM alterations in specific fiber orientations were found and these clusters were associated with outcome.Description
Keywords
diffusion tensor imaging, mild traumatic brain injury, outcome, tract-based spatial statistics, DIFFUSE AXONAL INJURY, CONSTRAINED SPHERICAL DECONVOLUTION, TENSOR IMAGING DETECTS, SPATIAL STATISTICS, CORPUS-CALLOSUM, WATER DIFFUSION, DTI, MRI, ABNORMALITIES, DYSMYELINATION
Other note
Citation
Mohammadian, M, Roine, T, Hirvonen, J, Kurki, T, Posti, J P, Katila, A J, Takala, R S K, Tallus, J, Maanpää, H-R, Frantzen, J, Hutchinson, P J, Newcombe, V F, Menon, D K & Tenovuo, O 2020, 'Alterations in Microstructure and Local Fiber Orientation of White Matter Are Associated with Outcome after Mild Traumatic Brain Injury', Journal of Neurotrauma, vol. 37, no. 24, pp. 2616-2623. https://doi.org/10.1089/neu.2020.7081