Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection
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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Journal of Advanced Research, Volume 38, pp. 223-244
Abstract
Background: Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them. Pathogenesis of neurological disorders is found to be associated with dysregulation of gut-brain axis. Some gut bacteria metabolites are found to be directly associated with the increase in reactive oxygen species levels, one of the most important risk factors of neurodegeneration. Besides their morbid association, gut bacteria metabolites are also found to play a significant role in reducing the onset of these life-threatening brain disorders. Aim of Review: Studies done in the recent past raises two most important link between gut microbiota and the brain: “gut microbiota-oxidative stress-neurodegeneration” and gut microbiota-antioxidant-neuroprotection. This review aims to gives a deep insight to our readers, of the collective studies done, focusing on the gut microbiota mediated oxidative stress involved in neurodegeneration along with a focus on those studies showing the involvement of gut microbiota and their metabolites in neuroprotection. Key Scientific Concepts of Review: This review is focused on three main key concepts. Firstly, the mounting evidences from clinical and preclinical arenas shows the influence of gut microbiota mediated oxidative stress resulting in dysfunctional neurological processes. Therefore, we describe the potential role of gut microbiota influencing the vulnerability of brain to oxidative stress, and a budding causative in Alzheimer's and Parkinson's disease. Secondly, contributing roles of gut microbiota has been observed in attenuating oxidative stress and inflammation via its own metabolites or by producing secondary metabolites and, also modulation in gut microbiota population with antioxidative and anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput in silico tools and databases also gives a correlation of gut microbiome, their metabolites and brain health, thus providing fascinating perspective and promising new avenues for therapeutic options.Description
Funding Information: Dr. Niraj Kumar Jha is currently working as an Assistant Professor in the Department of Biotechnology at Sharda University, Greater Noida, India. He is a former Assistant Professor of the faculty of Biotechnology, Noida Institute of Engineering and Technology (NIET), affiliated with Abdul Kalam Technical University (AKTU), India. He holds a doctorate in Biotechnology from Delhi Technological University (DTU) and a postgraduate degree in Biotechnology from Vellore Institute of Technology, TN, India. During the doctorate program, DBT granted him a fellowship as a financial boost to accomplish research work. He has published over 90 quality scholarly work and 5 book chapters in prestigious international journals and presented over 10 research papers in top national and international conferences. He is an editorial board member of various high repute international journals and assisted significantly in reviewing articles of many international journals such as Scientific reports, Life sciences, European journal of pharmaceutical sciences and Journal of food biochemistry. Currently, he is also serving as a guest editor for various top journals of international repute including Antioxidants, Environmental science and pollution research, Frontiers in Bioscience-Landmark and Immuno. He has executed various research projects and supervised several doctoral scholars, masters, and bachelor students. His vast research expertise covers the areas of Natural products, Cell signaling and Disease. Publisher Copyright: © 2021
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Shandilya, S, Kumar, S, Kumar Jha, N, Kumar Kesari, K & Ruokolainen, J 2022, 'Interplay of gut microbiota and oxidative stress : Perspective on neurodegeneration and neuroprotection', Journal of Advanced Research, vol. 38, pp. 223-244. https://doi.org/10.1016/j.jare.2021.09.005