Modelling and Simulation of Diauxic Growth

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Kemian tekniikan korkeakoulu | Bachelor's thesis
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Date

2025-05-09

Department

Major/Subject

Chemical Engineering

Mcode

CHEM3054

Degree programme

Aalto Bachelor's Programme in Science and Technology

Language

en

Pages

30

Series

Abstract

This paper aims to create a computer model that can simulate diauxic growth, and utilizes the methylotrophic yeast, P. pastoris, as a template to check the validity of the model. The developed model is capable of accurately predicting the diauxic growth pattern by measuring biomass, substrate and product concentrations. In addition, an optimisation program is written to find the best time to switch from glycerol to methanol feeding in a fedbatch reactor. This work advances the understanding of computer models for diauxic bioprocesses.

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Supervisor

Hummel, Michael

Thesis advisor

Eerikäinen, Tero

Keywords

pichia pastoris, bioreactor, diauxic growth

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https://urn.fi/URN:NBN:fi:aalto-202506174741

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[kand] Kemian tekniikan korkeakoulu / CHEM