Human ROBO1 Regulates Interaural Interaction in Auditory Pathways
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© 2012 Society for Neuroscience. This is the accepted version of the following article: Lamminmaki, S. & Massinen, S. & Nopola-Hemmi, J. & Kere, J. & Hari, Riitta. 2012. Human ROBO1 Regulates Interaural Interaction in Auditory Pathways. Journal of Neuroscience. Volume 32, Issue 3. 966-971. ISSN 0270-6474 (printed). DOI: 10.1523/jneurosci.4007-11.2012, which has been published in final form at http://www.jneurosci.org/content/32/3/966.full.
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School of Science |
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2012
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Mcode
Degree programme
Language
en
Pages
966-971
Series
Journal of Neuroscience, Volume 32, Issue 3
Abstract
In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.Description
Keywords
Robo1 gene, magnetoencephalography, dyslexia
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Citation
Lamminmaki, S. & Massinen, S. & Nopola-Hemmi, J. & Kere, J. & Hari, Riitta. 2012. Human ROBO1 Regulates Interaural Interaction in Auditory Pathways. Journal of Neuroscience. Volume 32, Issue 3. 966-971. ISSN 0270-6474 (printed). DOI: 10.1523/jneurosci.4007-11.2012.