aalto1 untyped-item.component.html
Cellular landscaping of cisplatin resistance in cervical cancer
Loading...
Access rights
openAccess
publishedVersion
URL
Journal Title
Journal ISSN
Volume Title
A2 Katsausartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Unless otherwise stated, all rights belong to the author. You may download, display and print this publication for Your own personal use. Commercial use is prohibited.
Date
Major/Subject
Mcode
Degree programme
Language
en
Pages
18
Series
Biomedicine & Pharmacotherapy, Volume 153, pp. 1-18
Abstract
Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.
Description
Publisher Copyright: © 2022 The Authors
Other note
Citation
Bhattacharjee, R, Dey, T, Kumar, L, Kar, S, Sarkar, R, Ghorai, M, Malik, S, Jha, N K, Vellingiri, B, Kesari, K K, Pérez de la Lastra, J M & Dey, A 2022, 'Cellular landscaping of cisplatin resistance in cervical cancer', Biomedicine & Pharmacotherapy, vol. 153, 113345, pp. 1-18. https://doi.org/10.1016/j.biopha.2022.113345