Towards the Total Synthesis of Manzaminoïds
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School of Chemical Engineering |
Doctoral thesis (monograph)
| Defence date: 2019-02-01
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Language
en
Pages
386
Series
Aalto University publication series DOCTORAL DISSERTATIONS, 19/2019
Abstract
For the last decades, our laboratory has been interested in the development of new synthetic methodologies and their application to the total syntheses of natural products exhibiting biological activities. In this context, our investigation focused on the conception of new potential bioactive manzamine derivatives. For this purpose, new molecules were synthetized using novel approaches of anionic polycyclization. Three methodologies were developed allowing to reach our targets. On top of that, some mechanistical analyses were made to rationalize the observed diastereoselectivities. Finally, the derivatisation of some target molecules allowed us to quickly extend our library of bioactive compounds.Description
This doctoral dissertation is completed under joint supervision cotutelle agreement to be defended for the degree of Doctor of Science (Technology) from Aalto University, and the degree of Docteur en Sciences from Université Catholique de Louvain (Université Catholique de Louvain publication series DOCTORAL DISSERTATIONS, Numéro de collection: 511, Domaine: SC).
Supervising professor
Koskinen, Ari, Prof., Aalto University, Department of Chemistry and Materials Science, FinlandRiant, Olivier, Prof., UCLouvain, France
Thesis advisor
Solberghe, Geoffrey, Dr., Union Chimique Belge, BelgiumDumeunier, Raphaël, Dr., Syngenta