Dose-response of intermittent theta burst stimulation of the prefrontal cortex : A TMS-EEG study
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2022-04
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Language
en
Pages
15
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Clinical Neurophysiology, Volume 136, pp. 158-172
Abstract
Objective: Using concurrent transcranial magnetic stimulation (TMS) and electroencephalography (TMS-EEG), this study aims to compare the effect of three intermittent theta-burst stimulation (iTBS) doses on cortical activity in the left dorsolateral prefrontal (DLPFC) cortex. Methods: Fourteen neurotypical participants took part in the following three experimental conditions: 600, 1200 and 1800 pulses. TMS-EEG recordings were conducted on the left DLPFC pre/post iTBS, including single-pulse TMS and short- and long-interval intracortical inhibition (SICI, LICI). TMS-evoked potentials (TEP) and event-related spectral perturbation (ERSP) were quantified. Linear mixed models were used to assess the effect of iTBS on brain activity. Results: The effects of iTBS on DLPFC activity did not significantly differ between the three doses. Specifically, regardless of dose, iTBS modulated the amplitude of most TEP components (P30, N45, P60, P200), reduced SICI and LICI ratios of P30 and P200, and decreased ERSP power of theta oscillations. Conclusions: In neurotypical individuals, doubling or tripling the number of iTBS pulses does not result in stronger potentiation of prefrontal activity. However, all iTBS conditions induced significant modulations of DLPFC activity. Significance: Replicating the study in clinical populations could help define optimal parameters for clinical applications.Description
Funding Information: ST was supported by a postdoctoral fellowship of the Canadian Institutes of Health Research (CIHR #338588). This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The team would like to thank Rogue Research Inc. and Brainbox Ltd. for the loan of a paired-pulse TMS device. Publisher Copyright: © 2022 International Federation of Clinical Neurophysiology
Keywords
Dorsolateral prefrontal cortex, Healthy subjects, iTBS, Neuroplasticity, rTMS, TMS-EEG
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Desforges, M, Hadas, I, Mihov, B, Morin, Y, Rochette Braün, M, Lioumis, P, Zomorrodi, R, Théoret, H, Lepage, M, Daskalakis, Z J & Tremblay, S 2022, ' Dose-response of intermittent theta burst stimulation of the prefrontal cortex : A TMS-EEG study ', Clinical Neurophysiology, vol. 136, pp. 158-172 . https://doi.org/10.1016/j.clinph.2021.12.018