Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via ?3-allylpalladium intermediates

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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2011

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en

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ORGANIC AND BIOMOLECULAR CHEMISTRY, Volume 9, issue 6, pp. 1774-1783

Abstract

A short route for the synthesis of Pachastrissamine (Jaspine B), an anhydrosphingosine derivative, and all three of its diastereomers is presented. The route consists of only 9 steps from the commercially available Garner’s aldehyde. The furan framework is formed via an h3-allylpalladium intermediate.

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Passiniemi, M & Koskinen, A M P 2011, ' Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via ?3-allylpalladium intermediates ', ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 9, no. 6, pp. 1774-1783 . https://doi.org/10.1039/C0OB00643B