Understanding mechanobiology – Linking the mechanical stimulation to cellular response

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Journal Title
Journal ISSN
Volume Title
Conference article in proceedings
Date
2019-03-12
Major/Subject
Mcode
Degree programme
Language
en
Pages
189-190
Series
Resumos alargados do 8º Congresso Nacional de Biomecânica, issue 1
Abstract
Mechanical loading plays a crucial role throughout humans’ lifetime since their embryonic development up to the tissues’ homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions, namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.
Description
Keywords
mechanobiology, mechanosensing, mechanotransduction, orthopedic implants
Other note
Citation
Melo-Fonseca , F , Mendes Pinto , I , Gasik , M , Silva , F S & Miranda , G 2019 , Understanding mechanobiology – Linking the mechanical stimulation to cellular response . in A Completo , A Ramos & A Faria (eds) , Resumos alargados do 8º Congresso Nacional de Biomecânica : 15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã . 1 edn , Universidade de Aveiro , Aveiro , pp. 189-190 , Congresso Nacional de Biomecânica , Covilhã , Portugal , 15/02/2019 . < https://ria.ua.pt/handle/10773/25495 >