Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorAltoè, Alessandro
dc.contributor.authorPulkki, Ville
dc.contributor.authorVerhulst, Sarah
dc.contributor.departmentDept Signal Process and Acoust
dc.contributor.departmentGhent University
dc.date.accessioned2018-08-01T13:33:23Z
dc.date.available2018-08-01T13:33:23Z
dc.date.issued2017-06-01
dc.description.abstractThis study proposes that the frequency tuning of the inner-hair-cell (IHC) stereocilia in the intact organ of Corti can be derived from the responses of the auditory fibers (AFs) using computational tools. The frequency-dependent relationship between the AF threshold and the amplitude of the stereocilia vibration is estimated using a model of the IHC-mediated mechanical to neural transduction. Depending on the response properties of the considered AF, the amplitude of stereocilia deflection required to drive the simulated AF above threshold is 1.4 to 9.2 dB smaller at low frequencies (≤500 Hz) than at high frequencies (≥4 kHz). The estimated frequency-dependent relationship between ciliary deflection and neural threshold is employed to derive constant-stereocilia-deflection contours from previously published AF recordings from the chinchilla cochlea. This analysis shows that the transduction process partially accounts for the observed differences between the tuning of the basilar membrane and that of the AFs.en
dc.description.versionPeer revieweden
dc.format.extent14
dc.format.extent4438-4451
dc.format.mimetypeapplication/pdf
dc.identifier.citationAltoè , A , Pulkki , V & Verhulst , S 2017 , ' Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves ' , Journal of the Acoustical Society of America , vol. 141 , no. 6 , pp. 4438-4451 . https://doi.org/10.1121/1.4985193en
dc.identifier.doi10.1121/1.4985193
dc.identifier.issn0001-4966
dc.identifier.issn1520-8524
dc.identifier.otherPURE UUID: be7fa42a-2dcb-4e9f-8c94-99dd88977589
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/be7fa42a-2dcb-4e9f-8c94-99dd88977589
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85020491391&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/26521416/1.4985193.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/32894
dc.identifier.urnURN:NBN:fi:aalto-201808014295
dc.language.isoenen
dc.relation.ispartofseriesJournal of the Acoustical Society of Americaen
dc.relation.ispartofseriesVolume 141, issue 6en
dc.rightsopenAccessen
dc.titleModel-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curvesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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