Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Journal of the Acoustical Society of America, Volume 141, issue 6
AbstractThis study proposes that the frequency tuning of the inner-hair-cell (IHC) stereocilia in the intact organ of Corti can be derived from the responses of the auditory fibers (AFs) using computational tools. The frequency-dependent relationship between the AF threshold and the amplitude of the stereocilia vibration is estimated using a model of the IHC-mediated mechanical to neural transduction. Depending on the response properties of the considered AF, the amplitude of stereocilia deflection required to drive the simulated AF above threshold is 1.4 to 9.2 dB smaller at low frequencies (≤500 Hz) than at high frequencies (≥4 kHz). The estimated frequency-dependent relationship between ciliary deflection and neural threshold is employed to derive constant-stereocilia-deflection contours from previously published AF recordings from the chinchilla cochlea. This analysis shows that the transduction process partially accounts for the observed differences between the tuning of the basilar membrane and that of the AFs.
Altoè , A , Pulkki , V & Verhulst , S 2017 , ' Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves ' , Journal of the Acoustical Society of America , vol. 141 , no. 6 , pp. 4438-4451 . https://doi.org/10.1121/1.4985193