Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2024-11-15
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Mcode
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en
Pages
11
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iScience, Volume 27, issue 11, pp. 1-11
Abstract
Neuronal oscillations are ubiquitous in brain activity at all scales and their synchronization dynamics are essential for information processing in neuronal systems. The underlying synaptic mechanisms, while mainly based on GABA- and glutamatergic neurotransmission, are influenced by neuromodulatory systems that have highly variable densities of neurotransmitter receptors and transporters across the cortical mantle. How they constrain the network structures of interacting oscillations has remained a central unaddressed question. We asked here whether the receptor and transporter densities covary with the frequency-specific neuroanatomical patterns of inter-areal phase synchrony (PS) and amplitude correlation (AC) networks in resting-state magnetoencephalography (MEG) data. Network centrality in delta and gamma frequencies covaried positively with GABA-, NMDA-, dopaminergic-, and most serotonergic receptor and transporter densities while covariance was negative in alpha and beta bands. These results show that local receptor microarchitecture shapes macro-scale oscillation networks in spectrally specific patterns.Description
Publisher Copyright: © 2024 The Author(s)
Keywords
Neuroscience, Sensory neuroscience
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Citation
Siebenhühner, F, Palva, J M & Palva, S 2024, ' Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks ', iScience, vol. 27, no. 11, 111111, pp. 1-11 . https://doi.org/10.1016/j.isci.2024.111111