Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Bioactive Materials, Volume 29
We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure–property–function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.
| openaire: EC/H2020/788489/EU//BioELCell Funding Information: The authors acknowledge the financial support from the São Paulo Research Foundation [FAPESP; Grants No. 2016/10636-8 , 2020/07956-6 , 2018/22214-6 , 2022/03247-6 ], the Brazilian National Council for Scientific and Technological Development [CNPq; ; Grants No 001 ], the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program [ERC Advanced Grant Agreement No. 788489 , “BioElCell”], the Canada Excellence Research Chair Program [ CERC-2018-00006 ], and Canada Foundation for Innovation [Project number 38623 ]. Publisher Copyright: © 2023 The Authors
Biomaterial, Cellulose nanocrystals, Cellulose nanofibrils, Green nanomaterials, Regenerative medicine, Sustainable materials
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Ferreira, F V, Souza, A G, Ajdary, R, de Souza, L P, Lopes, J H, Correa, D S, Siqueira, G, Barud, H S, Rosa, D D S, Mattoso, L H C & Rojas, O J 2023, ' Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine ', Bioactive Materials, vol. 29, pp. 151-176 .