Effective Intracerebral Connectivity in Acute Stroke: A TMS–EEG Study

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorTecchio, Franca
dc.contributor.authorGiambattistelli, Federica
dc.contributor.authorPorcaro, Camillo
dc.contributor.authorCottone, Carlo
dc.contributor.authorMutanen, Tuomas P.
dc.contributor.authorPizzella, Vittorio
dc.contributor.authorMarzetti, Laura
dc.contributor.authorIlmoniemi, Risto J.
dc.contributor.authorVernieri, Fabrizio
dc.contributor.authorRossini, Paolo Maria
dc.contributor.departmentNational Research Council of Italy
dc.contributor.departmentUniversita Campus Bio-Medico di Roma
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineering
dc.contributor.departmentGabriele d'Annunzio University
dc.contributor.departmentIRCCS San Raffaele Pisana - Roma
dc.date.accessioned2023-04-12T05:42:28Z
dc.date.available2023-04-12T05:42:28Z
dc.date.issued2023-02
dc.descriptionFunding Information: The work by TP Mutanen was supported by the Finnish Cultural Foundation (Grant No. 00161149) and the Academy of Finland (Grant No. 321631). The work by RJ Ilmoniemi was supported by funding from the Academy of Finland (Grant No. 307963) and from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 810377). | openaire: EC/H2020/810377/EU//ConnectToBrain
dc.description.abstractStroke is a major cause of disability because of its motor and cognitive sequelae even when the acute phase of stabilization of vital parameters is overcome. The most important improvements occur in the first 8–12 weeks after stroke, indicating that it is crucial to improve our understanding of the dynamics of phenomena occurring in this time window to prospectively target rehabilitation procedures from the earliest stages after the event. Here, we studied the intracortical excitability properties of delivering transcranial magnetic stimulation (TMS) to the primary motor cortex (M1) of left and right hemispheres in 17 stroke patients who suffered a mono-lateral left hemispheric stroke, excluding pure cortical damage. All patients were studied within 10 days of symptom onset. TMS-evoked potentials (TEPs) were collected via a TMS-compatible electroencephalogram system (TMS–EEG) concurrently with motor-evoked responses (MEPs) induced in the contralateral first dorsal interosseous muscle. Comparison with age-matched healthy volunteers was made by collecting the same bilateral-stimulation data in nine healthy volunteers as controls. Excitability in the acute phase revealed relevant changes in the relationship between left lesioned and contralesionally right hemispheric homologous areas both for TEPs and MEPs. While the paretic hand displayed reduced MEPs compared to the non-paretic hand and to healthy volunteers, TEPs revealed an overexcitable lesioned hemisphere with respect to both healthy volunteers and the contra-lesion side. Our quantitative results advance the understanding of the impairment of intracortical inhibitory networks. The neuronal dysfunction most probably changes the excitatory/inhibitory on-center off-surround organization that supports already acquired learning and reorganization phenomena that support recovery from stroke sequelae.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdf
dc.identifier.citationTecchio , F , Giambattistelli , F , Porcaro , C , Cottone , C , Mutanen , T P , Pizzella , V , Marzetti , L , Ilmoniemi , R J , Vernieri , F & Rossini , P M 2023 , ' Effective Intracerebral Connectivity in Acute Stroke: A TMS–EEG Study ' , Brain Sciences , vol. 13 , no. 2 , 233 . https://doi.org/10.3390/brainsci13020233en
dc.identifier.doi10.3390/brainsci13020233
dc.identifier.issn2076-3425
dc.identifier.otherPURE UUID: 43958f4b-8ff5-4faa-8c23-d1fbe6316f43
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/43958f4b-8ff5-4faa-8c23-d1fbe6316f43
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85148913584&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/105081213/Effective_Intracerebral_Connectivity_in_Acute_Stroke.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/120386
dc.identifier.urnURN:NBN:fi:aalto-202304122704
dc.language.isoenen
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/810377/EU//ConnectToBrain
dc.relation.ispartofseriesBRAIN SCIENCESen
dc.relation.ispartofseriesVolume 13, issue 2en
dc.rightsopenAccessen
dc.subject.keywordacute phase
dc.subject.keywordcenter-on surround-off
dc.subject.keywordcentral peripheral excitability
dc.subject.keywordelectromyography EMG
dc.subject.keywordstroke
dc.subject.keywordTMS–EEG
dc.titleEffective Intracerebral Connectivity in Acute Stroke: A TMS–EEG Studyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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