Biomimetic Total Synthesis of (±)-Lappaceolides A and B

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorPallerla, Rajanish R.
dc.contributor.authorHakola, Jenna
dc.contributor.authorHärkönen, Leevi
dc.contributor.authorSiitonen, Juha H.
dc.contributor.departmentDepartment of Chemistry and Materials Scienceen
dc.contributor.groupauthorETOS groupen
dc.contributor.groupauthorInorganic Materials Modellingen
dc.contributor.organizationAalto University
dc.contributor.organizationInorganic Materials Modelling
dc.date.accessioned2025-11-05T07:14:26Z
dc.date.available2025-11-05T07:14:26Z
dc.date.issued2025-10-10
dc.descriptionPublisher Copyright: © 2025 The Authors. Published by American Chemical Society
dc.description.abstractThe first total synthesis of lappaceolides A and B is achieved in two steps by using a biomimetic vinylogous-Michael–oxa-Michael domino reaction. The domino reaction proceeds with Cs2CO3in 1,2-DCE at elevated temperatures and requires careful kinetic control. The total synthesis provides further proof of the biosynthetic hypothesis of lappaceolides being dimers of the natural product siphonodin.en
dc.description.versionPeer revieweden
dc.format.extent3
dc.format.mimetypeapplication/pdf
dc.identifier.citationPallerla, R R, Hakola, J, Härkönen, L & Siitonen, J H 2025, 'Biomimetic Total Synthesis of (±)-Lappaceolides A and B', Organic Letters, vol. 27, no. 40, pp. 11149-11151. https://doi.org/10.1021/acs.orglett.5c02445en
dc.identifier.doi10.1021/acs.orglett.5c02445
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.otherPURE UUID: cc0661fc-d8ca-49cc-8a14-e4740c695b15
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/cc0661fc-d8ca-49cc-8a14-e4740c695b15
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/199803394/Biomimetic_Total_Synthesis_of_Lappaceolides_A_and_B.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/140541
dc.identifier.urnURN:NBN:fi:aalto-202511058698
dc.language.isoenen
dc.publisherAmerican Chemical Society
dc.relation.fundinginfoJ.H.S. acknowledges funding from Aalto University and FinnCERES.
dc.relation.ispartofseriesOrganic Lettersen
dc.relation.ispartofseriesVolume 27, issue 40, pp. 11149-11151en
dc.rightsopenAccessen
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleBiomimetic Total Synthesis of (±)-Lappaceolides A and Ben
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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