Biomimetic Total Synthesis of (±)-Lappaceolides A and B
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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3
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Organic Letters, Volume 27, issue 40, pp. 11149-11151
Abstract
The first total synthesis of lappaceolides A and B is achieved in two steps by using a biomimetic vinylogous-Michael–oxa-Michael domino reaction. The domino reaction proceeds with Cs2CO3in 1,2-DCE at elevated temperatures and requires careful kinetic control. The total synthesis provides further proof of the biosynthetic hypothesis of lappaceolides being dimers of the natural product siphonodin.Description
Publisher Copyright: © 2025 The Authors. Published by American Chemical Society
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Pallerla, R R, Hakola, J, Härkönen, L & Siitonen, J H 2025, 'Biomimetic Total Synthesis of (±)-Lappaceolides A and B', Organic Letters, vol. 27, no. 40, pp. 11149-11151. https://doi.org/10.1021/acs.orglett.5c02445