Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer

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Journal Title
Journal ISSN
Volume Title
A2 Katsausartikkeli tieteellisessä aikakauslehdessä
Date
2022-01-26
Major/Subject
Mcode
Degree programme
Language
en
Pages
16
1-16
Series
Molecular Cancer, Volume 21, issue 1
Abstract
Head and neck cancer is the sixth most common cancer across the globe. This is generally associated with tobacco and alcohol consumption. Cancer in the pharynx majorly arises through human papillomavirus (HPV) infection, thus classifying head and neck squamous cell carcinoma (HNSCC) into HPV-positive and HPV-negative HNSCCs. Aberrant, mesenchymal-epithelial transition factor (c-MET) signal transduction favors HNSCC progression by stimulating proliferation, motility, invasiveness, morphogenesis, and angiogenesis. c-MET upregulation can be found in the majority of head and neck squamous cell carcinomas. c-MET pathway acts on several downstream effectors including phospholipase C gamma (PLCγ), cellular Src kinase (c-Src), phosphotidylinsitol-3-OH kinase (PI3K), alpha serine/threonine-protein kinase (Akt), mitogen-activated protein kinase (MAPK), and wingless-related integration site (Wnt) pathways. c-MET also establishes a crosstalk pathway with epidermal growth factor receptor (EGFR) and contributes towards chemoresistance in HNSCC. In recent years, the signaling communications of c-MET/HGF in metabolic dysregulation, tumor-microenvironment and immune modulation in HNSCC have emerged. Several clinical trials have been established against c-MET/ hepatocyte growth factor (HGF) signaling network to bring up targeted and effective therapeutic strategies against HNSCC. In this review, we discuss the molecular mechanism(s) and current understanding of c-MET/HGF signaling and its effect on HNSCC. Graphical abstract: [Figure not available: see fulltext.]
Description
Funding Information: DK: Department of Science and Technology- Science and Engineering Research Board (DST-SERB) funded research grant (ECR/2016/001489), Govt. of India. Funding Information: Authors acknowledge Department of Science and Technology-Science and Engineering Research Board (DST- SERB), Government of India for partial financial support. Publisher Copyright: © 2022, The Author(s).
Keywords
C-MET, Chemoresistance, EGFR, Head and neck squamous cell carcinoma, Hepatocyte growth factor, Monoclonal antibody
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Citation
Raj, S, Kesari, K K, Kumar, A, Rathi, B, Sharma, A, Gupta, P K, Jha, S K, Jha, N K, Slama, P, Roychoudhury, S & Kumar, D 2022, ' Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer ', Molecular Cancer, vol. 21, no. 1, 31, pp. 1-16 . https://doi.org/10.1186/s12943-022-01503-1