Computer-aided production of scaffolded DNA nanostructures from flat sheet meshes

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorBenson, Erik
dc.contributor.authorMohammed, Abdulmelik
dc.contributor.authorBosco, Alessandro
dc.contributor.authorTeixeira, Ana I.
dc.contributor.authorOrponen, Pekka
dc.contributor.authorHögberg, Björn
dc.contributor.departmentKarolinska Institutet
dc.contributor.departmentDepartment of Computer Science
dc.date.accessioned2017-11-21T13:38:39Z
dc.date.available2017-11-21T13:38:39Z
dc.date.issued2016
dc.description.abstractThe use of DNA as a nanoscale construction material has been a rapidly developing field since the 1980s, in particular since the introduction of scaffolded DNA origami in 2006. Although software is available for DNA origami design, the user is generally limited to architectures where finding the scaffold path through the object is trivial. Herein, we demonstrate the automated conversion of arbitrary two-dimensional sheets in the form of digital meshes into scaffolded DNA nanostructures. We investigate the properties of DNA meshes based on three different internal frameworks in standard folding buffer and physiological salt buffers. We then employ the triangulated internal framework and produce four 2D structures with complex outlines and internal features. We demonstrate that this highly automated technique is capable of producing complex DNA nanostructures that fold with high yield to their programmed configurations, covering around 70 % more surface area than classic origami flat sheets.en
dc.description.versionPeer revieweden
dc.format.extent4
dc.format.extent8869-8872
dc.format.mimetypeapplication/pdf
dc.identifier.citationBenson , E , Mohammed , A , Bosco , A , Teixeira , A I , Orponen , P & Högberg , B 2016 , ' Computer-aided production of scaffolded DNA nanostructures from flat sheet meshes ' , Angewandte Chemie , vol. 55 , no. 31 , pp. 8869-8872 . https://doi.org/10.1002/anie.201602446en
dc.identifier.doi10.1002/anie.201602446
dc.identifier.issn1433-7851
dc.identifier.issn1521-3773
dc.identifier.otherPURE UUID: bc79115b-9da4-496b-8a5a-8512fc8ed8d3
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/bc79115b-9da4-496b-8a5a-8512fc8ed8d3
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=84977558196&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/15963413/flatsheets_2016.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/28852
dc.identifier.urnURN:NBN:fi:aalto-201711217673
dc.language.isoenen
dc.relation.ispartofseriesANGEWANDTE CHEMIEen
dc.relation.ispartofseriesVolume 55, issue 31en
dc.rightsopenAccessen
dc.subject.keywordatomic force microscopy
dc.subject.keywordDNA origami
dc.subject.keywordDNA structures
dc.subject.keywordmolecular simulation
dc.titleComputer-aided production of scaffolded DNA nanostructures from flat sheet meshesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionacceptedVersion
dc.type.versionpublishedVersion
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