Polymer ejection from strong spherical confinement

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2015
Major/Subject
Mcode
Degree programme
Language
en
Pages
1-6
Series
PHYSICAL REVIEW E, Volume 92, issue 6
Abstract
We examine the ejection of an initially strongly confined flexible polymer from a spherical capsid through a nanoscale pore. We use molecular dynamics for unprecedentedly high initial monomer densities. We show that the time for an individual monomer to eject grows exponentially with the number of ejected monomers. By measurements of the force at the pore we show this dependence to be a consequence of the excess free energy of the polymer due to confinement growing exponentially with the number of monomers initially inside the capsid. This growth relates closely to the divergence of mixing energy in the Flory-Huggins theory at large concentration. We show that the pressure inside the capsid driving the ejection dominates the process that is characterized by the ejection time growing linearly with the lengths of different polymers. Waiting time profiles would indicate that the superlinear dependence obtained for polymers amenable to computer simulations results from a finite-size effect due to the final retraction of polymers' tails from capsids.
Description
VK: Lampinen, J.; TRITON; CSC
Keywords
bacteriophage, capsid ejection, polymer physics, stochastic rotation dynamics, virus capsid
Other note
Citation
Piili , J & Linna , R P 2015 , ' Polymer ejection from strong spherical confinement ' , Physical Review E , vol. 92 , no. 6 , 062715 , pp. 1-6 . https://doi.org/10.1103/PhysRevE.92.062715