Polyelectrolyte Encapsulation and Confinement within Protein Cage-Inspired Nanocompartments

dc.contributorAalto Universityen
dc.contributor.authorLiu, Qingen_US
dc.contributor.authorShaukat, Ahmeden_US
dc.contributor.authorKyllönen, Daniellaen_US
dc.contributor.authorKostiainen, Mauri A.en_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.groupauthorBiohybrid Materialsen
dc.contributor.groupauthorCentre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials researchen
dc.contributor.organizationDepartment of Bioproducts and Biosystemsen_US
dc.description.abstractProtein cages are nanocompartments with a well-defined structure and monodisperse size. They are composed of several individual subunits and can be categorized as viral and non-viral protein cages. Native viral cages often exhibit a cationic interior, which binds the anionic nucleic acid genome through electrostatic interactions leading to efficient encapsulation. Non-viral cages can carry various cargo, ranging from small molecules to inorganic nanoparticles. Both cage types can be functionalized at targeted locations through genetic engineering or chemical modification to entrap materials through interactions that are inaccessible to wild-type cages. Moreover, the limited number of constitutional subunits ease the modification efforts, because a single modification on the subunit can lead to multiple functional sites on the cage surface. Increasing efforts have also been dedicated to the assembly of protein cage-mimicking structures or templated protein coatings. This review focuses on native and modified protein cages that have been used to encapsulate and package polyelectrolyte cargos and on the electrostatic interactions that are the driving force for the assembly of such structures. Selective encapsulation can protect the payload from the surroundings, shield the potential toxicity or even enhance the intended performance of the payload, which is appealing in drug or gene delivery and imaging.en
dc.description.versionPeer revieweden
dc.identifier.citationLiu, Q, Shaukat, A, Kyllönen, D & Kostiainen, M A 2021, ' Polyelectrolyte Encapsulation and Confinement within Protein Cage-Inspired Nanocompartments ', PHARMACEUTICS, vol. 13, no. 10, 1551 . https://doi.org/10.3390/pharmaceutics13101551en
dc.identifier.otherPURE UUID: 99daa2b8-47dc-4562-ac9c-8fe0d2eb79b3en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/99daa2b8-47dc-4562-ac9c-8fe0d2eb79b3en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/68090881/CHEM_Liu_et_al_Polyelectrolyte_Encapsulation_and_Confinement_2021_Pharmaceutics.pdfen_US
dc.publisherMDPI AG
dc.relation.ispartofseriesVolume 13, issue 10en
dc.titlePolyelectrolyte Encapsulation and Confinement within Protein Cage-Inspired Nanocompartmentsen
dc.typeA2 Katsausartikkeli tieteellisessä aikakauslehdessäfi