Opioidergic regulation of emotional arousal: A combined PET–fMRI study

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorKarjalainen, Tomi
dc.contributor.authorSeppälä, Kerttu
dc.contributor.authorGlerean, Enrico
dc.contributor.authorKarlsson, Henry K.
dc.contributor.authorLahnakoski, Juha
dc.contributor.authorNuutila, Pirjo
dc.contributor.authorJääskeläinen, Iiro
dc.contributor.authorHari, Riitta
dc.contributor.authorSams, Mikko
dc.contributor.authorNummenmaa, Lauri
dc.contributor.departmentTurku PET Centre
dc.contributor.departmentDepartment of Computer Science
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineering
dc.contributor.departmentUniversity of Turku
dc.contributor.departmentDepartment of Art
dc.date.accessioned2020-01-17T13:28:27Z
dc.date.available2020-01-17T13:28:27Z
dc.date.embargoinfo:eu-repo/date/embargoEnd/2020-09-01
dc.date.issued2019-09
dc.description.abstractEmotions can be characterized by dimensions of arousal and valence (pleasantness). While the functional brain bases of emotional arousal and valence have been actively investigated, the neuromolecular underpinnings remain poorly understood. We tested whether the opioid and dopamine systems involved in reward and motivational processes would be associated with emotional arousal and valence. We used in vivo positron emission tomography to quantify μ-opioid receptor and type 2 dopamine receptor (MOR and D2R, respectively) availability in brains of 35 healthy adult females. During subsequent functional magnetic resonance imaging carried out to monitor hemodynamic activity, the subjects viewed movie scenes of varying emotional content. Arousal and valence were associated with hemodynamic activity in brain regions involved in emotional processing, including amygdala, thalamus, and superior temporal sulcus. Cerebral MOR availability correlated negatively with the hemodynamic responses to arousing scenes in amygdala,hippocampus,thalamus, and hypothalamus, whereas no positive correlations were observed in any brain region. D2R availability—here reliably quantified only in striatum—was not associated with either arousal or valence. These results suggest that emotional arousal is regulated by the MOR system, and that cerebral MOR availability influences brain activity elicited by arousing stimuli.en
dc.description.versionPeer revieweden
dc.format.extent11
dc.format.extent4006–4016
dc.format.mimetypeapplication/pdf
dc.identifier.citationKarjalainen , T , Seppälä , K , Glerean , E , Karlsson , H K , Lahnakoski , J , Nuutila , P , Jääskeläinen , I , Hari , R , Sams , M & Nummenmaa , L 2019 , ' Opioidergic regulation of emotional arousal: A combined PET–fMRI study ' , Cerebral Cortex , vol. 29 , no. 9 , pp. 4006–4016 . https://doi.org/10.1093/cercor/bhy281en
dc.identifier.doi10.1093/cercor/bhy281
dc.identifier.issn1047-3211
dc.identifier.otherPURE UUID: 726bb580-6503-4dc2-9b32-05e36d5bc6bd
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/726bb580-6503-4dc2-9b32-05e36d5bc6bd
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/40353630/TKarjalainen_et_al_self_archival_copy.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/42525
dc.identifier.urnURN:NBN:fi:aalto-202001171640
dc.language.isoenen
dc.publisherOXFORD UNIV PRESS INC
dc.relation.ispartofseriesCerebral Cortexen
dc.relation.ispartofseriesVolume 29, issue 9en
dc.rightsopenAccessen
dc.subject.keyworddopamine
dc.subject.keywordfMRI
dc.subject.keywordPET
dc.subject.keywordneurotransmitters
dc.subject.keywordreceptor
dc.titleOpioidergic regulation of emotional arousal: A combined PET–fMRI studyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
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