Biomechanical features of graphene-augmented inorganic nanofibrous scaffolds and their physical interaction with viruses

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorGasik, Michael
dc.contributor.authorIvanov, Roman
dc.contributor.authorKazantseva, Jekaterina
dc.contributor.authorBilotsky, Yevgen
dc.contributor.authorHussainova, Irina
dc.contributor.departmentMaterials Processing and Powder Metallurgy
dc.contributor.departmentTallinn University of Technology
dc.contributor.departmentCenter of Food and Fermentation Technologies
dc.contributor.departmentUniversity of Helsinki
dc.contributor.departmentDepartment of Chemical and Metallurgical Engineeringen
dc.date.accessioned2021-01-25T10:19:24Z
dc.date.available2021-01-25T10:19:24Z
dc.date.issued2021-01-01
dc.description.abstractNanofibrous substrates and scaffolds are widely being studied as matrices for 3D cell cultures, and disease models as well as for analytics and diagnostic purposes. These scaffolds usually comprise randomly oriented fibers. Much less common are nanofibrous scaffolds made of stiff inorganic materials such as alumina. Well-aligned matrices are a promising tool for evaluation of behavior of biological objects affected by micro/nano-topologies as well as anisotropy. In this work, for the first time, we report a joint analysis of biomechanical properties of new ultra-anisotropic, self-aligned ceramic nanofibers augmented with two modifications of graphene shells (GAIN scaffolds) and their interaction of three different viral types (influenza virus A, picornavirus (human parechovirus) and potato virus). It was discovered that nano-topology and structure of the graphene layers have a significant implication on mechanical properties of GAIN scaffolds resulting in non-linear behavior. It was demonstrated that the viral adhesion to GAIN scaffolds is likely to be guided by physical cues in dependence on mutual steric factors, as the scaffolds lack common cell membrane proteins and receptors which viruses usually deploy for transfection. The study may have implications for selective viral adsorption, infected cells analysis, and potentially opening new tools for anti-viral drugs development.en
dc.description.versionPeer revieweden
dc.format.extent18
dc.format.extent1-18
dc.format.mimetypeapplication/pdf
dc.identifier.citationGasik , M , Ivanov , R , Kazantseva , J , Bilotsky , Y & Hussainova , I 2021 , ' Biomechanical features of graphene-augmented inorganic nanofibrous scaffolds and their physical interaction with viruses ' , Materials , vol. 14 , no. 1 , 164 , pp. 1-18 . https://doi.org/10.3390/ma14010164en
dc.identifier.doi10.3390/ma14010164
dc.identifier.issn1996-1944
dc.identifier.otherPURE UUID: f1975d76-6302-45cb-80c0-93b095127cd9
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/f1975d76-6302-45cb-80c0-93b095127cd9
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85099138625&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/55252982/materials_14_00164_v2.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/102288
dc.identifier.urnURN:NBN:fi:aalto-202101251598
dc.language.isoenen
dc.publisherMDPI AG
dc.relation.ispartofseriesMaterialsen
dc.relation.ispartofseriesVolume 14, issue 1en
dc.rightsopenAccessen
dc.subject.keywordAdherence
dc.subject.keywordAlumina
dc.subject.keywordAnisotropy
dc.subject.keywordBiomechanics
dc.subject.keywordGraphene
dc.subject.keywordNanofibers
dc.subject.keywordVirions
dc.titleBiomechanical features of graphene-augmented inorganic nanofibrous scaffolds and their physical interaction with virusesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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