Methanol-Driven Oxidative Rearrangement of Biogenic Furans – Enzyme Cascades vs. Photobiocatalysis

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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en

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6

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Frontiers in Chemistry, Volume 9

Abstract

The oxidative ring expansion of bio-derived furfuryl alcohols to densely functionalized six-membered O-heterocycles represents an attractive strategy in the growing network of valorization routes to synthetic building blocks out of the lignocellulosic biorefinery feed. In this study, two scenarios for the biocatalytic Achmatowicz-type rearrangement using methanol as terminal sacrificial reagent have been evaluated, comparing multienzymatic cascade designs with a photo-bio-coupled activation pathway.

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Funding Information: The authors gratefully acknowledge financial support by the Academy of Finland (298250, 309909 & 324976, JD) and the German Academic Exchange Service DAAD (MP) CJ thanks the Aalto School of Chemical Technology, as well as the Finnish Foundation for Technology Promotion and the Orion Research Foundation sr for personal grants. Publisher Copyright: © Copyright © 2021 Jäger, Bruneau, Wagner, Prechtl and Deska. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

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Jäger, C, Bruneau, C, Wagner, P K, Prechtl, M H G & Deska, J 2021, 'Methanol-Driven Oxidative Rearrangement of Biogenic Furans – Enzyme Cascades vs. Photobiocatalysis', Frontiers in Chemistry, vol. 9, 635883. https://doi.org/10.3389/fchem.2021.635883