Gating Patterns to Proprioceptive Stimulation in Various Cortical Areas: An MEG Study in Children and Adults using Spatial ICA

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorVallinoja, Jaakko
dc.contributor.authorJaatela, Julia
dc.contributor.authorNurmi, Timo
dc.contributor.authorPiitulainen, Harri
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineering
dc.date.accessioned2020-12-31T08:37:42Z
dc.date.available2020-12-31T08:37:42Z
dc.date.issued2020-11-03
dc.description.abstractProprioceptive paired-stimulus paradigm was used for 30 children (10–17 years) and 21 adult (25–45 years) volunteers in magnetoencephalography (MEG). Their right index finger was moved twice with 500-ms interval every 4 ± 25 s (repeated 100 times) using a pneumatic-movement actuator. Spatial-independent component analysis (ICA) was applied to identify stimulus-related components from MEG cortical responses. Clustering was used to identify spatiotemporally consistent components across subjects. We found a consistent primary response in the primary somatosensory (SI) cortex with similar gating ratios of 0.72 and 0.69 for the children and adults, respectively. Secondary responses with similar transient gating behavior were centered bilaterally in proximity of the lateral sulcus. Delayed and prolonged responses with strong gating were found in the frontal and parietal cortices possibly corresponding to larger processing network of somatosensory afference. No significant correlation between age and gating ratio was found. We confirmed that cortical gating to proprioceptive stimuli is comparable to other somatosensory and auditory domains, and between children and adults. Gating occurred broadly beyond SI cortex. Spatial ICA revealed several consistent response patterns in various cortical regions which would have been challenging to detect with more commonly applied equivalent current dipole or distributed source estimates.en
dc.description.versionPeer revieweden
dc.format.extent15
dc.format.mimetypeapplication/pdf
dc.identifier.citationVallinoja , J , Jaatela , J , Nurmi , T & Piitulainen , H 2020 , ' Gating Patterns to Proprioceptive Stimulation in Various Cortical Areas: An MEG Study in Children and Adults using Spatial ICA ' , Cerebral Cortex , vol. 31 , no. 3 . https://doi.org/10.1093/cercor/bhaa306en
dc.identifier.doi10.1093/cercor/bhaa306
dc.identifier.issn1047-3211
dc.identifier.otherPURE UUID: 1afa3aa0-74cf-4cef-a00a-6e5edc6baffc
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/1afa3aa0-74cf-4cef-a00a-6e5edc6baffc
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/53921404/Vallinoja_Gating_Patterns.bhaa306.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/101416
dc.identifier.urnURN:NBN:fi:aalto-2020123160237
dc.language.isoenen
dc.publisherOXFORD UNIV PRESS INC
dc.relation.ispartofseriesCerebral Cortexen
dc.rightsopenAccessen
dc.titleGating Patterns to Proprioceptive Stimulation in Various Cortical Areas: An MEG Study in Children and Adults using Spatial ICAen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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