Learning Centre

Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation

 |  Login

Show simple item record

dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Vergara Lourencon, Tainise
dc.contributor.author de Lima, Gabriel G.
dc.contributor.author Ribeiro, Carolina S. P.
dc.contributor.author Hansel, Fabrício A.
dc.contributor.author Maciel, Giselle M.
dc.contributor.author da Silva, Krisle
dc.contributor.author Winnischofer, Sheila M. B.
dc.contributor.author de Muniz, Graciela I. B.
dc.contributor.author Magalhães, Washington L E
dc.date.accessioned 2020-11-30T08:20:10Z
dc.date.available 2020-11-30T08:20:10Z
dc.date.issued 2021-01-01
dc.identifier.citation Vergara Lourencon , T , de Lima , G G , Ribeiro , C S P , Hansel , F A , Maciel , G M , da Silva , K , Winnischofer , S M B , de Muniz , G I B & Magalhães , W L E 2021 , ' Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation ' , International Journal of Biological Macromolecules , vol. 166 , pp. 1535-1542 . https://doi.org/10.1016/j.ijbiomac.2020.11.033 en
dc.identifier.issn 0141-8130
dc.identifier.other PURE UUID: dff2c43c-e0d4-4c0a-a4d6-101a35b93299
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/dff2c43c-e0d4-4c0a-a4d6-101a35b93299
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85096170242&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/53035003/CHEM_Lourencon_et_al_Antioxidant_antibacterial_and_antitumoural_activities_International_Journal_of_Biological_Macromolecules.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/61816
dc.description.abstract Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative material to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecular weight distribution and chemical composition heterogeneity led to the development of fractionation methods. Herein, to narrow such characteristics we used eucalypt kraft lignin fractionated at pH's 9, 7, 5 and 3 by sequential acid precipitation. These lignin fractions were first characterised by simultaneous pyrolysis and trimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxidant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increase in antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions precipitated at pH's 9 and 7 have shown an outstanding antibacterial activity against five bacteria. Moreover, fractions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G glioma cells, while only a slight inhibition of adult human fibroblasts (non-tumour cells) was detected. en
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Biological Macromolecules en
dc.rights openAccess en
dc.title Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Wood Material Science
dc.contributor.department Federal University of Paraná
dc.contributor.department Embrapa Florestas
dc.contributor.department Federal University of Technology
dc.contributor.department Universidade Federal do Paraná
dc.contributor.department Department of Bioproducts and Biosystems en
dc.subject.keyword IC50
dc.subject.keyword technical lignin
dc.subject.keyword radical scavenging
dc.subject.keyword antibacterial
dc.subject.keyword antitumoural
dc.subject.keyword hardwood lignin
dc.identifier.urn URN:NBN:fi:aalto-2020113020661
dc.identifier.doi 10.1016/j.ijbiomac.2020.11.033
dc.date.embargo info:eu-repo/date/embargoEnd/2021-11-10

Files in this item

Files Size Format View

There are no open access files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search archive

Advanced Search

article-iconSubmit a publication