Sonication methods and motion compensation for magnetic resonance guided high-intensity focused ultrasound

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Köhler, Max
dc.date.accessioned 2012-08-23T11:34:50Z
dc.date.available 2012-08-23T11:34:50Z
dc.date.issued 2009
dc.identifier.isbn 978-952-248-199-3
dc.identifier.isbn 978-952-248-198-6 (printed) #8195;
dc.identifier.issn 1795-4584
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/4698
dc.description.abstract High-intensity focused ultrasound (HIFU) is an efficient noninvasive therapeutic technique for localized heating of tissues deep within the human body through intact skin. Magnetic resonance imaging (MRI) can provide excellent soft-tissue contrast and can be used for both treatment planning and post-treatment assessment of the induced tissue damage. MRI can also provide temperature sensitive in vivo images via proton resonance frequency shift thermometry. Combined, the use of MRI and HIFU (MR-HIFU) ablation make for a promising therapeutic modality for controlled and noninvasive selective tissue destruction. Sonication strategies, MR thermometry methods, feedback control, and motion compensation for MR-HIFU were developed and evaluated in this thesis. The primary aim of the thesis was to develop a safe and efficient strategy for clinical MR-HIFU ablation. An efficient volumetric method of ablation was achieved by utilizing the phased-array capabilities of the transducer and the inherent heat diffusion of already deposited heat. The induced temperature rise was monitored with rapid multiplane MR thermometry with a volumetric coverage of the heated region. Acquisition and display of temperature images during sonication improved the safety of the therapy. The therapeutic procedure was evaluated in a large animal model and proved to provide a substantial improvement in efficiency as compared to existing methods without compromising safety. The second aim was to improve the reliability of the proposed volumetric sonication strategy. This was achieved with a simple and robust binary feedback algorithm that adjusted the sonication duration of each part of the sonication trajectory based on the temperature rise as obtained by volumetric MR thermometry. The feedback algorithm was evaluated in a large animal model, and was found to reduce the variability in thermal lesion size by approximately 70%. The third aim was to develop a through-plane motion correction method for real-time MR thermometry without disturbing thermometry. This was achieved with a fat-selective navigator. This navigator outperformed the conventional navigator for direct tracking of the kidney under free breathing. The navigator also provided accurate indexing of the look-up-table used to correct the reference phase for MR thermometry of mobile organs. Finally, the combination of through-plane motion correction provided by the fat-selective navigator with existing methods of in-plane motion correction and reference phase correction, allowed for an accurate 3D motion compensation of both MR thermometry and MR-HIFU sonication. en
dc.format.extent Verkkokirja (4099 KB, 118 s.)
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Teknillinen korkeakoulu en
dc.relation.ispartofseries TKK dissertations, 199 en
dc.relation.haspart [Publication 1]: M.O. Köhler, C. Mougenot, B. Quesson, J. Enholm, B. Le Bail, C. Laurent, C.T.W. Moonen, and G.J. Ehnholm. Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry. Medical Physics 2009;36(8):3521-3535. en
dc.relation.haspart [Publication 2]: J.K. Enholm, M.O. Köhler, B. Quesson, C. Mougenot, C.T.W. Moonen, and S.D. Sokka. Improved Volumetric MR-HIFU Ablation by Robust Binary Feedback Control. IEEE Transactions on Biomedical Engineering 2009, In press. en
dc.relation.haspart [Publication 3]: M.O. Köhler, C.T.W. Moonen, and M. Ries. Spectral Selective Pencil-Beam Navigator for Abdominal Imaging. Helsinki University of Technology Publications in Engineering Physics, Report TKK-F-A860. en
dc.relation.haspart [Publication 4]: S. Hey, G. Maclair, B. Denis de Senneville, M. Lepetit-Coiffé, Y. Berber, M.O. Köhler, B. Quesson, C.T.W. Moonen, and M. Ries. Online correction of respiratory-induced field disturbances for continuous MR-thermometry in the breast. Magnetic Resonance in Medicine 2009;61(6):1494-1499. en
dc.relation.haspart [Publication 5]: M. Köhler, G. Maclair, B. Denis de Senneville, C. Moonen, and M. Ries. 3D Navigated Real-Time Thermometry for Abdominal Imaging. In: Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Canada, 2008 (abstract 1226). en
dc.subject.other Medical sciences en
dc.title Sonication methods and motion compensation for magnetic resonance guided high-intensity focused ultrasound en
dc.type G5 Artikkeliväitöskirja fi
dc.contributor.department Lääketieteellisen tekniikan ja laskennallisen tieteen laitos fi
dc.subject.keyword HIFU en
dc.subject.keyword MR thermometry en
dc.subject.keyword MR-HIFU en
dc.subject.keyword sonication en
dc.subject.keyword ablation en
dc.subject.keyword feedback control en
dc.subject.keyword motion compensation en
dc.identifier.urn URN:ISBN:978-952-248-199-3
dc.type.dcmitype text en
dc.type.ontasot Väitöskirja (artikkeli) fi
dc.type.ontasot Doctoral dissertation (article-based) en


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