All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Costa, Clarinda; Liu, Zehua; Martins, João P.; Correia, Alexandra; Figueiredo, Patrícia; Rahikkala, Antti; Li, Wei; Seitsonen, Jani; Ruokolainen, Janne; Hirvonen, Sami Pekka; Aguiar-Ricardo, Ana; Corvo, M. Luísa; Santos, Hélder A.

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All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

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Title:	All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery
Author(s):	Costa, Clarinda ; Liu, Zehua ; Martins, João P. ; Correia, Alexandra ; Figueiredo, Patrícia ; Rahikkala, Antti ; Li, Wei ; Seitsonen, Jani ; Ruokolainen, Janne ; Hirvonen, Sami Pekka ; Aguiar-Ricardo, Ana ; Corvo, M. Luísa ; Santos, Hélder A.
Date:	2020-06-21
Language:	en
Pages:	8 3270-3277
Department:	Department of Applied Physics
Series:	Biomaterials Science, Volume 8, issue 12
ISSN:	2047-4830
DOI-number:	10.1039/d0bm00743a
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This publication is imported from Aalto University Research information portal: https://research.aalto.fi > View this publication in Research information portal > Other link related to publication (Research information portal) > View/Open full text file from Research information portal
Citation: Costa , C , Liu , Z , Martins , J P , Correia , A , Figueiredo , P , Rahikkala , A , Li , W , Seitsonen , J , Ruokolainen , J , Hirvonen , S P , Aguiar-Ricardo , A , Corvo , M L & Santos , H A 2020 , ' All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery ' , Biomaterials Science , vol. 8 , no. 12 , pp. 3270-3277 . https://doi.org/10.1039/d0bm00743a
Abstract: Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

Permanent link to this item: http://urn.fi/URN:NBN:fi:aalto-202008124720 Email this Export to RefWorks QR Code Print BibTex Tweet