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ADHD desynchronizes brain activity during watching a distracted multi-talker conversation

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Salmitaival, Juha
dc.contributor.author Metwaly, Mostafa
dc.contributor.author Tohka, Jussi
dc.contributor.author Alho, Kimmo
dc.contributor.author Leppämäki, Sami
dc.contributor.author Tani, Pekka
dc.contributor.author Koski, Anniina
dc.contributor.author Vanderwal, Tamara
dc.contributor.author Laine, Matti
dc.date.accessioned 2020-04-03T09:50:31Z
dc.date.available 2020-04-03T09:50:31Z
dc.date.issued 2020-08-01
dc.identifier.citation Salmitaival , J , Metwaly , M , Tohka , J , Alho , K , Leppämäki , S , Tani , P , Koski , A , Vanderwal , T & Laine , M 2020 , ' ADHD desynchronizes brain activity during watching a distracted multi-talker conversation ' , NeuroImage , vol. 216 , 116352 . https://doi.org/10.1016/j.neuroimage.2019.116352 en
dc.identifier.issn 1053-8119
dc.identifier.issn 1095-9572
dc.identifier.other PURE UUID: a98f5cd7-0bab-46d7-b15e-f3e90ebdf6d9
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/a98f5cd7-0bab-46d7-b15e-f3e90ebdf6d9
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/41696158/1_s2.0_S1053811919309437_main.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/43688
dc.description.abstract Individuals with attention-deficit/hyperactivity disorder (ADHD) have difficulties navigating dynamic everyday situations that contain multiple sensory inputs that need to either be attended to or ignored. As conventional experimental tasks lack this type of everyday complexity, we administered a film-based multi-talker condition with auditory distractors in the background. ADHD-related aberrant brain responses to this naturalistic stimulus were identified using intersubject correlations (ISCs) in functional magnetic resonance imaging (fMRI) data collected from 51 adults with ADHD and 29 healthy controls. A novel permutation-based approach introducing studentized statistics and subject-wise voxel-level null-distributions revealed that several areas in cerebral attention networks and sensory cortices were desynchronized in participants with ADHD (n = 20) relative to healthy controls (n = 20). Specifically, desynchronization of the posterior parietal cortex occurred when irrelevant speech or music was presentedin the background, but not when irrelevant white noise was presented, or when there were no distractors. We also show regionally distinct ISC signatures for inattention and impulsivity. Finally, post-scan recall of the film contents was associated with stronger ISCs in the default-mode network for the ADHD and in the dorsal attention network for healthy controls. The present study shows that ISCs can further our understanding of how a complex environment influences brain states in ADHD. en
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries NeuroImage en
dc.rights openAccess en
dc.title ADHD desynchronizes brain activity during watching a distracted multi-talker conversation en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Neuroscience and Biomedical Engineering
dc.contributor.department University of Helsinki
dc.contributor.department University of Eastern Finland
dc.contributor.department University of British Columbia
dc.contributor.department Åbo Akademi University
dc.identifier.urn URN:NBN:fi:aalto-202004032718
dc.identifier.doi 10.1016/j.neuroimage.2019.116352
dc.type.version publishedVersion

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