Left hemisphere enhancement of auditory activation in language impaired children

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author van Bijnen, Sam
dc.contributor.author Kärkkäinen, Salme
dc.contributor.author Helenius, Päivi
dc.contributor.author Parviainen, Tiina
dc.date.accessioned 2019-07-30T07:21:16Z
dc.date.available 2019-07-30T07:21:16Z
dc.date.issued 2019-12-01
dc.identifier.citation van Bijnen , S , Kärkkäinen , S , Helenius , P & Parviainen , T 2019 , ' Left hemisphere enhancement of auditory activation in language impaired children ' , Scientific Reports , vol. 9 , no. 1 , 9087 , pp. 1-11 . https://doi.org/10.1038/s41598-019-45597-y en
dc.identifier.issn 2045-2322
dc.identifier.other PURE UUID: e92c12c7-bf71-406d-af37-9465d02cf400
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/left-hemisphere-enhancement-of-auditory-activation-in-language-impaired-children(e92c12c7-bf71-406d-af37-9465d02cf400).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85067873473&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/35123418/s41598_019_45597_y.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/39522
dc.description | openaire: EC/H2020/641652/EU//ChildBrain
dc.description.abstract Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development. en
dc.format.extent 1-11
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher NATURE PUBLISHING GROUP
dc.relation info:eu-repo/grantAgreement/EC/H2020/641652/EU//ChildBrain
dc.relation.ispartofseries Scientific Reports en
dc.relation.ispartofseries Volume 9, issue 1 en
dc.rights openAccess en
dc.subject.other General en
dc.subject.other 3112 Neurosciences en
dc.title Left hemisphere enhancement of auditory activation in language impaired children en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department University of Jyvaskyla
dc.contributor.department University of Helsinki
dc.contributor.department Department of Neuroscience and Biomedical Engineering en
dc.subject.keyword General
dc.subject.keyword 3112 Neurosciences
dc.identifier.urn URN:NBN:fi:aalto-201907304577
dc.identifier.doi 10.1038/s41598-019-45597-y
dc.type.version publishedVersion


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